Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients

Ching Wei Hsu; Ja Liang Lin; Dan Tzu Lin-Tan; Kuan Hsing Chen; Tzung Hai Yen; Mai Szu Wu; Shih Chieh Lin

doi:10.1371/journal.pone.0048397

Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients

Ching Wei Hsu, Ja Liang Lin, Dan Tzu Lin-Tan, Kuan Hsing Chen, Tzung Hai Yen, Mai Szu Wu, Shih Chieh Lin

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP

Original language	English
Article number	e48397
Journal	PLoS One
Volume	7
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0048397
Publication status	Published - Oct 29 2012
Externally published	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Access to Document

10.1371/journal.pone.0048397

Fingerprint Dive into the research topics of 'Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients'. Together they form a unique fingerprint.

Cite this

@article{b5f128bffb3042288b72749ae0eb49af,

title = "Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients",

abstract = "Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP ",

author = "Hsu, {Ching Wei} and Lin, {Ja Liang} and Lin-Tan, {Dan Tzu} and Chen, {Kuan Hsing} and Yen, {Tzung Hai} and Wu, {Mai Szu} and Lin, {Shih Chieh}",

year = "2012",

month = oct,

day = "29",

doi = "10.1371/journal.pone.0048397",

language = "English",

volume = "7",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "10",

}

TY - JOUR

T1 - Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients

AU - Hsu, Ching Wei

AU - Lin, Ja Liang

AU - Lin-Tan, Dan Tzu

AU - Chen, Kuan Hsing

AU - Yen, Tzung Hai

AU - Wu, Mai Szu

AU - Lin, Shih Chieh

PY - 2012/10/29

Y1 - 2012/10/29

N2 - Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP

AB - Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP

UR - http://www.scopus.com/inward/record.url?scp=84868087242&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868087242&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0048397

DO - 10.1371/journal.pone.0048397

M3 - Article

C2 - 23144759

AN - SCOPUS:84868087242

VL - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 10

M1 - e48397

ER -