Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients

Ching Wei Hsu, Ja Liang Lin, Dan Tzu Lin-Tan, Kuan Hsing Chen, Tzung Hai Yen, Mai Szu Wu, Shih Chieh Lin

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Abstract

Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP

Original languageEnglish
Article numbere48397
JournalPLoS One
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 29 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hsu, C. W., Lin, J. L., Lin-Tan, D. T., Chen, K. H., Yen, T. H., Wu, M. S., & Lin, S. C. (2012). Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients. PLoS One, 7(10), [e48397]. https://doi.org/10.1371/journal.pone.0048397