Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients

Ching Wei Hsu, Ja Liang Lin, Dan Tzu Lin-Tan, Kuan Hsing Chen, Tzung Hai Yen, Mai Szu Wu, Shih Chieh Lin

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP

Original languageEnglish
Article numbere48397
JournalPLoS One
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 29 2012
Externally publishedYes

Fingerprint

Hemoperfusion
Paraquat
cyclophosphamide
paraquat
Cyclophosphamide
Methylprednisolone
dexamethasone
Dexamethasone
Survival
Developing countries
developing countries
poisoning
mouth
Animals
therapeutics
Developing Countries
dosage
animals
Mortality
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hsu, C. W., Lin, J. L., Lin-Tan, D. T., Chen, K. H., Yen, T. H., Wu, M. S., & Lin, S. C. (2012). Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients. PLoS One, 7(10), [e48397]. https://doi.org/10.1371/journal.pone.0048397

Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients. / Hsu, Ching Wei; Lin, Ja Liang; Lin-Tan, Dan Tzu; Chen, Kuan Hsing; Yen, Tzung Hai; Wu, Mai Szu; Lin, Shih Chieh.

In: PLoS One, Vol. 7, No. 10, e48397, 29.10.2012.

Research output: Contribution to journalArticle

Hsu, CW, Lin, JL, Lin-Tan, DT, Chen, KH, Yen, TH, Wu, MS & Lin, SC 2012, 'Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients', PLoS One, vol. 7, no. 10, e48397. https://doi.org/10.1371/journal.pone.0048397
Hsu, Ching Wei ; Lin, Ja Liang ; Lin-Tan, Dan Tzu ; Chen, Kuan Hsing ; Yen, Tzung Hai ; Wu, Mai Szu ; Lin, Shih Chieh. / Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients. In: PLoS One. 2012 ; Vol. 7, No. 10.
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