Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients

Ching Wei Hsu; Ja Liang Lin; Dan Tzu Lin-Tan; Kuan Hsing Chen; Tzung Hai Yen; Mai Szu Wu; Shih Chieh Lin

doi:10.1371/journal.pone.0048397

Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients

Ching Wei Hsu, Ja Liang Lin, Dan Tzu Lin-Tan, Kuan Hsing Chen, Tzung Hai Yen, Mai Szu Wu, Shih Chieh Lin

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP

Original language	English
Article number	e48397
Journal	PLoS One
Volume	7
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0048397
Publication status	Published - Oct 29 2012
Externally published	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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abstract = "Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP ",

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AU - Hsu, Ching Wei

AU - Lin, Ja Liang

AU - Lin-Tan, Dan Tzu

AU - Chen, Kuan Hsing

AU - Yen, Tzung Hai

AU - Wu, Mai Szu

AU - Lin, Shih Chieh

PY - 2012/10/29

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N2 - Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP

AB - Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP

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Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients

Abstract

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