Abstract
Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP
| Original language | English |
|---|---|
| Article number | e48397 |
| Journal | PLoS One |
| Volume | 7 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 29 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients. / Hsu, Ching Wei; Lin, Ja Liang; Lin-Tan, Dan Tzu; Chen, Kuan Hsing; Yen, Tzung Hai; Wu, Mai Szu; Lin, Shih Chieh.
In: PLoS One, Vol. 7, No. 10, e48397, 29.10.2012.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Early Hemoperfusion May Improve Survival of Severely Paraquat-Poisoned Patients
AU - Hsu, Ching Wei
AU - Lin, Ja Liang
AU - Lin-Tan, Dan Tzu
AU - Chen, Kuan Hsing
AU - Yen, Tzung Hai
AU - Wu, Mai Szu
AU - Lin, Shih Chieh
PY - 2012/10/29
Y1 - 2012/10/29
N2 - Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP
AB - Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries. Although animal studies indicate that hemoperfusion (HP) within 2-4 h after intoxication effectively reduces mortality, the effect of early HP in humans remains unknown. Methods: We analyzed the records of all PQ-poisoned patients admitted to 2 hospitals between 2000 and 2009. Patients were grouped according to early or late HP and high-dose (oral cyclophosphamide [CP] and intravenous dexamethasone [DX]) or repeated pulse (intravenous methylprednisolone [MP] and CP, followed by DX and repeated MP and/or CP) PQ therapy. Early HP was defined as HP
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U2 - 10.1371/journal.pone.0048397
DO - 10.1371/journal.pone.0048397
M3 - Article
C2 - 23144759
AN - SCOPUS:84868087242
VL - 7
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 10
M1 - e48397
ER -