Early diagnosis of ventriculoperitoneal shunt infections and malfunctions in children with hydrocephalus

Cheng Chou Lan, Tai-Tong Wong, Shu Jen Chen, Muh Lii Liang, Ren Bin Tang

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

This retrospective study assessed the parameters of ventriculoperitoneal shunt infection and malfunction found in 129 children with hydrocephalus who had undergone a ventriculoperitoneal shunt placement at Taipei Veterans General Hospital from January 1997 to June 2001. The clinical characteristics and differences among these patients were reviewed to determine the potential predictors of shunt infection and malfunction. Fever (60%, 6/ 10) and seizure (40%, 4/10) occurred significantly more often in the infection group than in the malfunction and control groups (p<0.05). A higher blood C-reactive protein level was noted in the infection group than in the malfunction and control groups (p<0.05). Examination of the cerebrospinal fluid of infected patients showed significantly higher white blood cell count and neutrophil count, higher protein concentration, and lower glucose levels compared with the other 2 groups (p<0.05). However, the number of patients with cerebrospinal fluid eosinophilia was significantly higher in the malfunction group (p<0.05). The diagnostic usefulness of laboratory parameters in patients with ventriculoperitoneal shunt infection is as follow: cerebrospinal fluid white blood cell count over 100/mm 3, 96% specificity and a positive predictive value of 0.55; and cerebrospinal fluid neutrophils over 10%, 90% sensitivity and a negative predictive value of 0.99. In conclusion, Fever, seizure, high blood C-reactive protein, combined with leukocytosis, neutrophil over 10%, low glucose level, and high protein level in the ventricular fluid are factors that may help in distinguishing shunt infection from shunt malfunction.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalJournal of Microbiology, Immunology and Infection
Volume36
Issue number1
Publication statusPublished - Mar 1 2003
Externally publishedYes

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Ventriculoperitoneal Shunt
Hydrocephalus
Early Diagnosis
Cerebrospinal Fluid
Infection
Neutrophils
Leukocyte Count
C-Reactive Protein
Blood Proteins
Veterans Hospitals
Glucose
Febrile Seizures
Control Groups
Leukocytosis
Eosinophilia
General Hospitals
Seizures
Proteins
Fever
Retrospective Studies

Keywords

  • Hydrocephalus
  • Infection
  • Malfunction
  • Ventriculoperitoneal shunt

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

Cite this

Early diagnosis of ventriculoperitoneal shunt infections and malfunctions in children with hydrocephalus. / Lan, Cheng Chou; Wong, Tai-Tong; Chen, Shu Jen; Liang, Muh Lii; Tang, Ren Bin.

In: Journal of Microbiology, Immunology and Infection, Vol. 36, No. 1, 01.03.2003, p. 47-50.

Research output: Contribution to journalArticle

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