Early changes of the anemia phenomenon in male 100-km ultramarathoners

Yu Hui Chiu, Jiun I. Lai, Shih Hao Wang, Chorng Kuang How, Li Hua Li, Wei Fong Kao, Chen Chang Yang, Ray Jade Chen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Sports anemia is a widely observed phenomenon after prolonged running. There are various factors that contribute to sports anemia, including hemodilution, exercise-induced oxidative stress, iron deficiency, gastrointestinal bleeding, hematuria, and hemolysis resulting from foot-strike and/or from compression of contracting muscles on capillaries. Until now, there has been no published report that describes the overall hematological, urinary, and fecal consequences in Asian male ultramarathoners after a 100-km (62.5-mile) ultramarathon event. Methods: A total of 25 male runners were recruited into our study. Blood was drawn 1 week before, immediately after, and then 24 hours subsequent to the race. Hematological samples were analyzed for the anemia phenomenon. Additionally, urinary and fecal samples were collected before and after the race for detection of occult blood. Results: The blood hemoglobin and erythropoietin values of the recruited runners showed a statistically significant rise in the immediate post-race values and a rapid drop in values at 24 hours post-race. Blood concentrations of red blood cells and hematocrit were significantly lower at 24 hours post-race compared with pre-race. The white blood cell count, interleukin-6, tumor necrosis factor-alpha, high-sensitivity C-reactive protein, and ferritin all showed significant increases both immediately after and 24 hours post-race compared with pre-race hematological values. There were immediate decreases of both haptoglobin and iron, as well as an increase of total iron-binding capacity levels in post-race blood tests. For both urinary and fecal samples, there was a statistically significant difference between the pre- and post-race results in occult blood. Conclusion: Running a 100-km ultramarathon will induce substantial sports anemia, and oxidative stress response, hemolysis, hematuria, and gastrointestinal bleeding are typical factors that contribute to its onset.

Original languageEnglish
Pages (from-to)108-113
Number of pages6
JournalJournal of the Chinese Medical Association
Volume78
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Fingerprint

Anemia
Sports
Occult Blood
Iron
Hematuria
Hemolysis
Running
Oxidative Stress
Hemorrhage
Hemodilution
Haptoglobins
Hematologic Tests
Ferritins
Erythropoietin
Leukocyte Count
Hematocrit
C-Reactive Protein
Foot
Interleukin-6
Hemoglobins

Keywords

  • Clinical sports medicine
  • Exercise-induced hemolysis
  • Oxidative stress response
  • Sports anemia
  • Ultramarathon

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Early changes of the anemia phenomenon in male 100-km ultramarathoners. / Chiu, Yu Hui; Lai, Jiun I.; Wang, Shih Hao; How, Chorng Kuang; Li, Li Hua; Kao, Wei Fong; Yang, Chen Chang; Chen, Ray Jade.

In: Journal of the Chinese Medical Association, Vol. 78, No. 2, 01.02.2015, p. 108-113.

Research output: Contribution to journalArticle

Chiu, Yu Hui ; Lai, Jiun I. ; Wang, Shih Hao ; How, Chorng Kuang ; Li, Li Hua ; Kao, Wei Fong ; Yang, Chen Chang ; Chen, Ray Jade. / Early changes of the anemia phenomenon in male 100-km ultramarathoners. In: Journal of the Chinese Medical Association. 2015 ; Vol. 78, No. 2. pp. 108-113.
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AU - How, Chorng Kuang

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AU - Kao, Wei Fong

AU - Yang, Chen Chang

AU - Chen, Ray Jade

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AB - Background: Sports anemia is a widely observed phenomenon after prolonged running. There are various factors that contribute to sports anemia, including hemodilution, exercise-induced oxidative stress, iron deficiency, gastrointestinal bleeding, hematuria, and hemolysis resulting from foot-strike and/or from compression of contracting muscles on capillaries. Until now, there has been no published report that describes the overall hematological, urinary, and fecal consequences in Asian male ultramarathoners after a 100-km (62.5-mile) ultramarathon event. Methods: A total of 25 male runners were recruited into our study. Blood was drawn 1 week before, immediately after, and then 24 hours subsequent to the race. Hematological samples were analyzed for the anemia phenomenon. Additionally, urinary and fecal samples were collected before and after the race for detection of occult blood. Results: The blood hemoglobin and erythropoietin values of the recruited runners showed a statistically significant rise in the immediate post-race values and a rapid drop in values at 24 hours post-race. Blood concentrations of red blood cells and hematocrit were significantly lower at 24 hours post-race compared with pre-race. The white blood cell count, interleukin-6, tumor necrosis factor-alpha, high-sensitivity C-reactive protein, and ferritin all showed significant increases both immediately after and 24 hours post-race compared with pre-race hematological values. There were immediate decreases of both haptoglobin and iron, as well as an increase of total iron-binding capacity levels in post-race blood tests. For both urinary and fecal samples, there was a statistically significant difference between the pre- and post-race results in occult blood. Conclusion: Running a 100-km ultramarathon will induce substantial sports anemia, and oxidative stress response, hemolysis, hematuria, and gastrointestinal bleeding are typical factors that contribute to its onset.

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