Abstract
Nasopharyngeal carcinoma (NPC) is an endemic head and neck epithelial malignancy in Southeastern Asia and Taiwan. The E2 factor (E2F) family of transcription factors is downstream targets of the retinoblastoma protein 1. The E2F family of transcription factors is the key regulator of genes involved in cell cycle progression, cell fate determination, DNA damage repair and apoptosis. E2F1 is unique in that it contributes both to the control of cellular proliferation and cellular death. However, the expression of E2F1 protein and its clinicopathological associations in patients with NPC are yet to be evaluated. Immunoexpression of E2F1 was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The outcomes were correlated with clinicopathological features and patient survivals. Results indicated that high E2F1 protein level (50%) was correlated with primary tumor (pth American Joint Committee on Cancer). In multivariate analyses, high E2F1 expression emerged as an independent prognosticator for worse disease-specific survival (p=0.003), distal metastasis-free survival (p=0.003), and local recurrence-free survival (p=0.039). In conclusion, high E2F1 protein level is common, associated with adverse prognosticators, and might confer tumor aggressiveness through tumor cell proliferation and metastasis.
| Original language | English |
|---|---|
| Pages (from-to) | 23-30 |
| Number of pages | 8 |
| Journal | Biomarkers and Genomic Medicine |
| Volume | 5 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2013 |
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Keywords
- E2F transcription factor 1
- Nasopharyngeal carcinoma
- Survival
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biomedical Engineering
- Medicine(all)
- Drug Discovery
Cite this
E2F transcription factor 1 overexpression as a poor prognostic factor in patients with nasopharyngeal carcinomas. / Li, Chien Feng; Chen, Li Tzong; Lin, Ching Yih; Huang, Hsuan Ying; Hsing, Chung Hsi; Huang, Chiang Ting; Shiue, Yow Ling.
In: Biomarkers and Genomic Medicine, Vol. 5, No. 1-2, 2013, p. 23-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - E2F transcription factor 1 overexpression as a poor prognostic factor in patients with nasopharyngeal carcinomas
AU - Li, Chien Feng
AU - Chen, Li Tzong
AU - Lin, Ching Yih
AU - Huang, Hsuan Ying
AU - Hsing, Chung Hsi
AU - Huang, Chiang Ting
AU - Shiue, Yow Ling
PY - 2013
Y1 - 2013
N2 - Nasopharyngeal carcinoma (NPC) is an endemic head and neck epithelial malignancy in Southeastern Asia and Taiwan. The E2 factor (E2F) family of transcription factors is downstream targets of the retinoblastoma protein 1. The E2F family of transcription factors is the key regulator of genes involved in cell cycle progression, cell fate determination, DNA damage repair and apoptosis. E2F1 is unique in that it contributes both to the control of cellular proliferation and cellular death. However, the expression of E2F1 protein and its clinicopathological associations in patients with NPC are yet to be evaluated. Immunoexpression of E2F1 was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The outcomes were correlated with clinicopathological features and patient survivals. Results indicated that high E2F1 protein level (50%) was correlated with primary tumor (pth American Joint Committee on Cancer). In multivariate analyses, high E2F1 expression emerged as an independent prognosticator for worse disease-specific survival (p=0.003), distal metastasis-free survival (p=0.003), and local recurrence-free survival (p=0.039). In conclusion, high E2F1 protein level is common, associated with adverse prognosticators, and might confer tumor aggressiveness through tumor cell proliferation and metastasis.
AB - Nasopharyngeal carcinoma (NPC) is an endemic head and neck epithelial malignancy in Southeastern Asia and Taiwan. The E2 factor (E2F) family of transcription factors is downstream targets of the retinoblastoma protein 1. The E2F family of transcription factors is the key regulator of genes involved in cell cycle progression, cell fate determination, DNA damage repair and apoptosis. E2F1 is unique in that it contributes both to the control of cellular proliferation and cellular death. However, the expression of E2F1 protein and its clinicopathological associations in patients with NPC are yet to be evaluated. Immunoexpression of E2F1 was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The outcomes were correlated with clinicopathological features and patient survivals. Results indicated that high E2F1 protein level (50%) was correlated with primary tumor (pth American Joint Committee on Cancer). In multivariate analyses, high E2F1 expression emerged as an independent prognosticator for worse disease-specific survival (p=0.003), distal metastasis-free survival (p=0.003), and local recurrence-free survival (p=0.039). In conclusion, high E2F1 protein level is common, associated with adverse prognosticators, and might confer tumor aggressiveness through tumor cell proliferation and metastasis.
KW - E2F transcription factor 1
KW - Nasopharyngeal carcinoma
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84883762085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883762085&partnerID=8YFLogxK
U2 - 10.1016/j.gmbhs.2013.04.006
DO - 10.1016/j.gmbhs.2013.04.006
M3 - Article
VL - 5
SP - 23
EP - 30
JO - Genomic Medicine, Biomarkers, and Health Sciences
JF - Genomic Medicine, Biomarkers, and Health Sciences
SN - 2214-0247
IS - 1-2
ER -