Dynamic effects of respiration on aortic blood flow and its autonomic control in rats

Cheryl C H Yang, Inga T Y Yeh, Hsien Yong Lai, Hsing I. Chen, Terry B J Kuo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. Respiratory related arterial pressure variability may reflect body fluid status and/or cardiac sympathetic function. The underlying mechanism is not clear. 2. In the present study, we used an electromagnetic blood flow meter to measure ascending aortic blood flow, from which stroke volume was integrated, to study respiration-stroke volume coupling and its underlying neural regulation. Experiments were performed on male Sprague-Dawley rats that were anaesthetized with pentobarbital sodium, paralysed with pancuronium and under mechanical ventilation. 3. Programmed irregular ventilation evoked significant variability in arterial pressure, aortic flow and stroke volume signals. Good coupling was noted between lung volume and aortic flow, as well as between lung volume and stroke volume; this coupling persisted under all experimental conditions. The aortic flow power and stroke volume variability and the transfer magnitude of the lung volume-aortic flow and lung volume-stroke volume couplings were suppressed by 1 mg/kg propranolol, but not by 0.3 mg/kg atropine or a combination of 0.3 mg/kg atropine and 2.5 mg/kg phentolamine. 4. These results suggest that respiratory related variability in aortic flow and stroke volume, which ultimately contributes to arterial pressure variability, is primarily under cardiac sympathetic control via β-adrenoceptors in anaesthetized and mechanically ventilated rats.

Original languageEnglish
Pages (from-to)1294-1300
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Volume35
Issue number11
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Fingerprint

Stroke Volume
Respiration
Lung
Arterial Pressure
Atropine
Pancuronium
Phentolamine
Electromagnetic Phenomena
Body Fluids
Pentobarbital
Artificial Respiration
Propranolol
Adrenergic Receptors
Sprague Dawley Rats
Ventilation

Keywords

  • β-adrenoceptor control
  • Arterial pressure variability
  • Autospectra
  • Broad-band mechanical ventilation
  • Cross-spectra
  • Stroke volume

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Dynamic effects of respiration on aortic blood flow and its autonomic control in rats. / Yang, Cheryl C H; Yeh, Inga T Y; Lai, Hsien Yong; Chen, Hsing I.; Kuo, Terry B J.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 35, No. 11, 11.2008, p. 1294-1300.

Research output: Contribution to journalArticle

Yang, Cheryl C H ; Yeh, Inga T Y ; Lai, Hsien Yong ; Chen, Hsing I. ; Kuo, Terry B J. / Dynamic effects of respiration on aortic blood flow and its autonomic control in rats. In: Clinical and Experimental Pharmacology and Physiology. 2008 ; Vol. 35, No. 11. pp. 1294-1300.
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