Duration of red blood cell storage and inflammatory marker generation

Caroline Sut, Sofiane Tariket, Ming Li Chou, Olivier Garraud, Sandrine Laradi, Hind Hamzeh-Cognasse, Jerard Seghatchian, Thierry Burnouf, Fabrice Cognasse

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Red blood cell (RBC) transfusion is a life-saving treatment for several pathologies. RBCs for transfusion are stored refrigerated in a preservative solution, which extends their shelf-life for up to 42 days. During storage, the RBCs endure abundant physicochemical changes, named RBC storage lesions, which affect the overall quality standard, the functional integrity and in vivo survival of the transfused RBCs. Some of the changes occurring in the early stages of the storage period (for approximately two weeks) are reversible but become irreversible later on as the storage is extended. In this review, we aim to decipher the duration of RBC storage and inflammatory marker generation. This phenomenon is included as one of the causes of transfusion-related immunomodulation (TRIM), an emerging concept developed to potentially elucidate numerous clinical observations that suggest that RBC transfusion is associated with increased inflammatory events or effects with clinical consequence.

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalBlood Transfusion
Volume15
Issue number2
DOIs
Publication statusPublished - Mar 1 2017

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Erythrocyte Transfusion
Erythrocytes
Immunomodulation
Pathology
Therapeutics

Keywords

  • Inflammation
  • Red blood cell
  • Storage

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology

Cite this

Sut, C., Tariket, S., Chou, M. L., Garraud, O., Laradi, S., Hamzeh-Cognasse, H., ... Cognasse, F. (2017). Duration of red blood cell storage and inflammatory marker generation. Blood Transfusion, 15(2), 145-152. https://doi.org/10.2450/2017.0343-16

Duration of red blood cell storage and inflammatory marker generation. / Sut, Caroline; Tariket, Sofiane; Chou, Ming Li; Garraud, Olivier; Laradi, Sandrine; Hamzeh-Cognasse, Hind; Seghatchian, Jerard; Burnouf, Thierry; Cognasse, Fabrice.

In: Blood Transfusion, Vol. 15, No. 2, 01.03.2017, p. 145-152.

Research output: Contribution to journalReview article

Sut, C, Tariket, S, Chou, ML, Garraud, O, Laradi, S, Hamzeh-Cognasse, H, Seghatchian, J, Burnouf, T & Cognasse, F 2017, 'Duration of red blood cell storage and inflammatory marker generation', Blood Transfusion, vol. 15, no. 2, pp. 145-152. https://doi.org/10.2450/2017.0343-16
Sut C, Tariket S, Chou ML, Garraud O, Laradi S, Hamzeh-Cognasse H et al. Duration of red blood cell storage and inflammatory marker generation. Blood Transfusion. 2017 Mar 1;15(2):145-152. https://doi.org/10.2450/2017.0343-16
Sut, Caroline ; Tariket, Sofiane ; Chou, Ming Li ; Garraud, Olivier ; Laradi, Sandrine ; Hamzeh-Cognasse, Hind ; Seghatchian, Jerard ; Burnouf, Thierry ; Cognasse, Fabrice. / Duration of red blood cell storage and inflammatory marker generation. In: Blood Transfusion. 2017 ; Vol. 15, No. 2. pp. 145-152.
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