Dual-Targeting Glycol Chitosan/Heparin-Decorated Polypyrrole Nanoparticle for Augmented Photothermal Thrombolytic Therapy

Ting Yu Lu, Chih Yu Chiang, Yu Jui Fan, Pei Ru Jheng, Edgar Daniel Quiñones, Kuan Ting Liu, Shuo Hsiu Kuo, Han Yun Hsieh, Ching Li Tseng, Jiashing Yu, Er Yuan Chuang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Near-infrared (NIR)-light-modulated photothermal thrombolysis has been investigated to overcome the hemorrhage danger posed by clinical clot-busting substances. A long-standing issue in thrombosis fibrinolytics is the lack of lesion-specific therapy, which should not be ignored. Herein, a novel thrombolysis therapy using photothermal disintegration of a fibrin clot was explored through dual-targeting glycol chitosan/heparin-decorated polypyrrole nanoparticles (GCS-PPY-H NPs) to enhance thrombus delivery and thrombolytic therapeutic efficacy. GCS-PPY-H NPs can target acidic/P-selectin high-expression inflammatory endothelial cells/thrombus sites for initiating lesion-site-specific thrombolysis by hyperthermia using NIR irradiation. A significant fibrin clot-clearance rate was achieved with thrombolysis using dual-targeting/modality photothermal clot disintegration in vivo. The molecular level mechanisms of the developed nanoformulations and interface properties were determined using multiple surface specific analytical techniques, such as particle size distribution, zeta potential, electron microscopy, Fourier-transform infrared spectroscopy (FTIR), wavelength absorbance, photothermal, immunofluorescence, and histology. Owing to the augmented thrombus delivery of GCS-PPY-H NPs and swift treatment time, dual-targeting photothermal clot disintegration as a systematic treatment using GCS-PPY-H NPs can be effectively applied in thrombolysis. This novel approach possesses a promising future for thrombolytic treatment.

Original languageEnglish
Pages (from-to)10287-10300
Number of pages14
JournalACS Applied Materials and Interfaces
Volume13
Issue number8
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • dual targeting
  • nanoparticle
  • P-selectin
  • photothermal thrombolytic treatment
  • thrombosis

ASJC Scopus subject areas

  • Materials Science(all)

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