Dual Stimuli-Responsive Nucleobase-Functionalized Polymeric Systems as Efficient Tools for Manipulating Micellar Self-Assembly Behavior

Belete Tewabe Gebeyehu, Shan You Huang, Ai Wei Lee, Jem Kun Chen, Juin Yih Lai, Duu Jong Lee, Chih Chia Cheng

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Environmental stimuli-responsive nucleobase-functionalized supramolecular polymers, a combination of oligomeric polypropylene glycol segments as a thermosensitive element and hydrogen-bonded uracil as a photosensitive moiety, were successfully developed and undergo spontaneous self-assembly to form uniform nanosized micelles via self-complementary double hydrogen bonding interactions between the uracil moieties in an aqueous environment. These micelles exhibit unique properties such as dual thermo- and photoresponsiveness, controllable lower critical concentration solution temperature (LCST), photoreactivity, and morphological transformation, making them highly attractive for various applications. More importantly, phase transitions and morphological studies confirmed the LCST behavior, size, and shape of the micelles can be easily tuned by adjusting the concentration and duration of ultraviolet irradiation of samples in aqueous solution, indicating introduction of uracil molecules into a water-soluble polymer matrix may represent a promising approach toward development of multiple stimuli-responsive polymeric micelles whose self-assembly behavior can be manipulated. In view of the ease of fabrication, high biocompatibility, multifunctionality, and tailorable micellar properties, this newly developed supramolecular micelle may be a promising candidate nanocarrier for controlled drug delivery and bioimaging systems.

Original languageEnglish
Pages (from-to)1189-1197
Number of pages9
JournalMacromolecules
Volume51
Issue number3
DOIs
Publication statusPublished - Feb 13 2018

Fingerprint

Micelles
Self assembly
Uracil
Photoreactivity
Controlled drug delivery
Glycols
Polymer matrix
Biocompatibility
Chemical elements
Polypropylenes
Hydrogen
Hydrogen bonds
Polymers
Phase transitions
Irradiation
Fabrication
Temperature
Molecules
Water

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

Cite this

Dual Stimuli-Responsive Nucleobase-Functionalized Polymeric Systems as Efficient Tools for Manipulating Micellar Self-Assembly Behavior. / Gebeyehu, Belete Tewabe; Huang, Shan You; Lee, Ai Wei; Chen, Jem Kun; Lai, Juin Yih; Lee, Duu Jong; Cheng, Chih Chia.

In: Macromolecules, Vol. 51, No. 3, 13.02.2018, p. 1189-1197.

Research output: Contribution to journalArticle

Gebeyehu, Belete Tewabe ; Huang, Shan You ; Lee, Ai Wei ; Chen, Jem Kun ; Lai, Juin Yih ; Lee, Duu Jong ; Cheng, Chih Chia. / Dual Stimuli-Responsive Nucleobase-Functionalized Polymeric Systems as Efficient Tools for Manipulating Micellar Self-Assembly Behavior. In: Macromolecules. 2018 ; Vol. 51, No. 3. pp. 1189-1197.
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