Recent studies underscore the need to target tumor progenitors that have been shown to be resistant to conventional chemotherapeutic agents. The present study was designed to discover novel compounds with activity against drug-resistant ovarian tumor-initiating cells (OTICs).
Lai, H., Yo, Y. W., Wang, Y., Balch, C., Huang, R., Chang, C., Nephew, K. P., & Huang, T. (2013). Drug screening identifies growth inhibition of ovarian tumor-initiating cells by niclosamide. Gynecologic Oncology, 130(1), e132. https://doi.org/10.1016/j.ygyno.2013.04.378