Drug resistance patterns of tuberculosis in Taiwan

I. Hsin Chiang, Ming Chih Yu, Kuan Jen Bai, Ming Pin Wu, Chih Jen Hsu, Tao Ping Lin, Kwen Tay Luh

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22 Citations (Scopus)

Abstract

To evaluate the patterns of drug resistance of Mycobacterium tuberculosis in Taiwan, a total of 1,091 isolates collected from patients from January 1996 through December 1996 were tested for drug susceptibility using the absolute concentration method at the Taiwan Provincial Chronic Disease Control Bureau. The overall drug rate of resistance to at least one drug was 35.5%. Among the 249 isolates from patients who had never been treated for tuberculosis, 16.1% were resistant to one or more drugs; 1.6% were resistant to at least isoniazid and rifampin. Of 200 patients with prior antituberculosis treatment, 67.0% had isolates resistant to one or more drugs and 46.0% had isolates resistant to at least isoniazid and rifampin. We conclude that drug-resistant M. tuberculosis is an important issue in tuberculosis treatment in Taiwan, especially when dealing with patients with a prior history of antituberculosis treatment. More aggressive interventions, such as directly observed therapy, short-course, are needed to improve the cure rate of pulmonary tuberculosis and to decrease resistance rates.

Original languageEnglish
Pages (from-to)581-583
Number of pages3
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume97
Issue number8
Publication statusPublished - Aug 1998
Externally publishedYes

Keywords

  • Drug resistance
  • Multidrug-resistant tuberculosis
  • Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

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    Chiang, I. H., Yu, M. C., Bai, K. J., Wu, M. P., Hsu, C. J., Lin, T. P., & Luh, K. T. (1998). Drug resistance patterns of tuberculosis in Taiwan. Journal of the Formosan Medical Association = Taiwan yi zhi, 97(8), 581-583.