Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan

Jen J. Lee, Chun N. Lee, Jen Suo, I. Hsin Chiang, Chin B. Lin, Teng Y. Lin, Yeong C. Tsai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To evaluate patterns of drug resistance of Mycobacterium tuberculosis in eastern Taiwan. Materials and Methods: Two hundred and fifty-two isolates collected from January 2001 through December 2002 were tested for drug susceptibility using the agar proportion method at Tzu Chi General Hospital. Results: The overall rate of resistance to at least one drug was 28.6%. The overall resistance rates to individual drugs were 21.8% to isoniazid, 8.3% to streptomycin, 12.7% to rifampin, and 12.7% to ethambutol. Among the 190 isolates from patients without prior treatment, 16.8% of the strains were resistant to at least one drug. Resistance to isoniazid (11.1%), ethambutol (5.8%), or streptomycin (5.3%) was more common than resistance to rifampin (2.1%). The prevalence of primary multidrug resistance was 2.1%. Among the 62 isolates from patients with histories of anti-TB treatment, the prevalence of resistance to any of the four drugs was 64.5%. The acquired resistance rates to individual drugs were 54.8% to isoniazid, 17.7% to streptomycin, 45.2% to rifampin, and 33.9% to ethambutol. Conclusions: The prevalence of drug resistance is very high in eastern Taiwan, and the surveys for anti-tuberculosis drug resistance should be repeated annually. Measures to decrease the multidrug-resistance rate are greatly needed.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalTzu Chi Medical Journal
Volume15
Issue number4
Publication statusPublished - Aug 2003

Fingerprint

Taiwan
Mycobacterium tuberculosis
Drug Resistance
Ethambutol
Isoniazid
Streptomycin
Rifampin
Pharmaceutical Preparations
Multiple Drug Resistance
General Hospitals
Agar
Tuberculosis
Therapeutics

Keywords

  • Acquired drug resistance
  • Mycobacterium tuberculosis
  • Primary drug resistance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lee, J. J., Lee, C. N., Suo, J., Chiang, I. H., Lin, C. B., Lin, T. Y., & Tsai, Y. C. (2003). Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan. Tzu Chi Medical Journal, 15(4), 229-234.

Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan. / Lee, Jen J.; Lee, Chun N.; Suo, Jen; Chiang, I. Hsin; Lin, Chin B.; Lin, Teng Y.; Tsai, Yeong C.

In: Tzu Chi Medical Journal, Vol. 15, No. 4, 08.2003, p. 229-234.

Research output: Contribution to journalArticle

Lee, JJ, Lee, CN, Suo, J, Chiang, IH, Lin, CB, Lin, TY & Tsai, YC 2003, 'Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan', Tzu Chi Medical Journal, vol. 15, no. 4, pp. 229-234.
Lee JJ, Lee CN, Suo J, Chiang IH, Lin CB, Lin TY et al. Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan. Tzu Chi Medical Journal. 2003 Aug;15(4):229-234.
Lee, Jen J. ; Lee, Chun N. ; Suo, Jen ; Chiang, I. Hsin ; Lin, Chin B. ; Lin, Teng Y. ; Tsai, Yeong C. / Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan. In: Tzu Chi Medical Journal. 2003 ; Vol. 15, No. 4. pp. 229-234.
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