Drug release from hydroxypropyl cellulose and polyethylene oxide capsules: In vitro and in vivo assessment

Chien Yuan Lee, Gan Lin Chen, Ming Thau Sheu, Cheng Hsiung Liu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this study, hard capsule shells produced using a heat-melting method, which involved heating polyethylene oxide (PEO, with a molecular weight (MW) of 200,000) or hydroxypropyl cellulose (HPC, with MWs of 80,000,100,000, and 370,000) powder in a mold, followed by inserting a suitably sized pestle in the mold in order to coat the melted shell materials (HPC or PEO) onto the pestle with a certain force. The water uptake and dissolution tests of these capsule shells were evaluated in acidic buffer, basic buffer, and water. Theophylline was selected as the model drug. The drug release rate decreased with increasing viscosity grades of HPC used as the shell material. In vivo studies were conducted in rabbits with the novel capsules, and comparisons were made with gelatin capsules. It was found that the pharmacokinetic parameters, including AUC0-∞ and T1/2, showed no significant differences among the various capsules. Correlations between the in vitro TD50 values and several in vivo parameters were established.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalChinese Pharmaceutical Journal
Volume58
Issue number1
Publication statusPublished - Feb 2006

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Keywords

  • Dissolution
  • Hard capsules
  • Heat-melting method
  • Hydroxypropyl cellulose
  • Pharmacokinetics
  • Polyethylene oxide
  • Theophylline

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Bioengineering

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