Drug release from glutaraldehyde-treated fibrin gels

H. O. Ho, M. T. Sheu, T. D. Sokoloski, C. Y. Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Glutaraldehyde treatment of dexamethasone-containing cylindrical fibrin gels (obtained by the thrombin-induced polymerization of fibrinogen in the presence of the drug) causes cross-linking of the gels and modification of the pore structure. The effect on the release of dexamethasone was assessed by measuring the diffusion coefficient of the drug across treated and untreated gels; diffusion across the treated gels was significantly decreased as compared with untreated gels, but was little affected by the concentration of glutaraldehyde uses in the treatment. In biodegradable tests, the treated gels (all concentrations of glutaraldehyde) were resistant to digestion even in the presence of plasmin, but untreated gels were digested, and the digestion rate was accelerated by plasmin. The volume of the gels was progressively reduced as the concentration of glutaraldehyde was increased or the amount of fibrinogen was decreased, but the extent of the reduction did not correlate with the changes in the diffusion coefficient.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalDrug Design and Delivery
Volume7
Issue number1
Publication statusPublished - 1990

Fingerprint

Glutaral
Fibrin
Gels
Fibrinolysin
Fibrinogen
Dexamethasone
Digestion
Drug Liberation
Thrombin
Polymerization
Pharmaceutical Preparations

Keywords

  • biodegradability
  • cylindrical model
  • dexamethasone phosphate
  • diffusion coefficient
  • fibrin gels

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Pharmacology

Cite this

Drug release from glutaraldehyde-treated fibrin gels. / Ho, H. O.; Sheu, M. T.; Sokoloski, T. D.; Chen, C. Y.

In: Drug Design and Delivery, Vol. 7, No. 1, 1990, p. 65-73.

Research output: Contribution to journalArticle

Ho, HO, Sheu, MT, Sokoloski, TD & Chen, CY 1990, 'Drug release from glutaraldehyde-treated fibrin gels', Drug Design and Delivery, vol. 7, no. 1, pp. 65-73.
Ho, H. O. ; Sheu, M. T. ; Sokoloski, T. D. ; Chen, C. Y. / Drug release from glutaraldehyde-treated fibrin gels. In: Drug Design and Delivery. 1990 ; Vol. 7, No. 1. pp. 65-73.
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