Dried fruit of the Luffa sponge as a source of chitin for applications as skin substitutes

Ping Lun Jiang, Mei Yin Chien, Ming Thau Sheu, Yi You Huang, Meng Hsun Chen, Ching-Hua Su, Der Zen Liu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

LUFFACHITIN obtained from the residue of the sponge-like dried fruit of Luffa aegyptiaca was developed as a weavable skin substitute in this study. A chemical analysis revealed that LUFFACHITIN was composed of a copolymer containing N-acetyl-glucosamine (40%) as a major monomer with a filamentary structure as demonstrated by both optical and scanning electron microscopy. The pulp-like white residue of the sponge-like dried fruit of Luffa aegyptiaca after treatment was then woven into a thin, porous membrane by filtration and lyophilization as a skin substitute for conducting wound-healing study on rats. The results indicated that the LUFFACHITIN membrane showed significant wound-healing enhancement (25 days to complete healing) compared to cotton gauze (>30 days), but not inferior to that of SACCHACHITIN. Furthermore, the LUFFACHITIN membrane had advantages of having a high yield, better physical properties for fabrication, and a more attractive appearance.

Original languageEnglish
Article number458287
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Luffa
Artificial Skin
Chitin
Porifera
Fruits
Fruit
Membranes
Wound Healing
Freeze Drying
Glucosamine
Electron Scanning Microscopy
Cotton
Pulp
Rats
Copolymers
Physical properties
Monomers
Fabrication
Scanning electron microscopy
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Dried fruit of the Luffa sponge as a source of chitin for applications as skin substitutes. / Jiang, Ping Lun; Chien, Mei Yin; Sheu, Ming Thau; Huang, Yi You; Chen, Meng Hsun; Su, Ching-Hua; Liu, Der Zen.

In: BioMed Research International, Vol. 2014, 458287, 2014.

Research output: Contribution to journalArticle

Jiang, Ping Lun ; Chien, Mei Yin ; Sheu, Ming Thau ; Huang, Yi You ; Chen, Meng Hsun ; Su, Ching-Hua ; Liu, Der Zen. / Dried fruit of the Luffa sponge as a source of chitin for applications as skin substitutes. In: BioMed Research International. 2014 ; Vol. 2014.
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AU - Chen, Meng Hsun

AU - Su, Ching-Hua

AU - Liu, Der Zen

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