Abstract

Objective: To investigate alterations of integrin αv, survival and apoptosis signaling pathways in uterine leiomyomas. Materials and Methods: In a prospective study of 50 women with uterine leiomyomas that had been pathologically confirmed, specimens were obtained laparoscopically from 2007 to 2009. The expressions of integrin αv signaling pathways (Ras/Raf/ERK1/2, Akt and cleaved caspase-3), surface microstructures by surface electron microscopy and immunohistochemical findings were assessed. Results: The study yielded novel results: (1) the integrin αv expression approached a low level (mRNA 0.39 ± 0.06, protein 0.47 ± 0.08) with coherent alterations of its downstream signaling molecules (Ras, p-c-Raf, p-ERK1/2) (p <0.001); (2) smoother surface microstructures of uterine leiomyomas were correlated with low integrin αv expressions, and (3) survival signaling and apoptosis signaling were significantly down- and upregulated respectively (p <0.001). Conclusion: Integrin αv and related survival signaling pathways were downregulated, but the apoptosis was upregulated in uterine leiomyomas. Benign smooth-contoured tumors may have low integrin expressions and cancer invasion potentials.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalGynecologic and Obstetric Investigation
Volume71
Issue number2
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Leiomyoma
Integrins
Down-Regulation
Apoptosis
Survival
Caspase 3
Neoplasms
Electron Microscopy
Prospective Studies
Messenger RNA
Proteins

Keywords

  • Cell adhesion molecules
  • Integrins
  • Surface electron microscopy
  • Uterine leiomyoma

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Downregulation of the integrin αv signaling pathway in uterine leiomyomas. / Tsai, Feng-Chou; Liu, Wei-Min; Pai, Man-Hui; Hsieh, Ming-Shium; Lin, Jui Yu; Chou, Chih-Ming.

In: Gynecologic and Obstetric Investigation, Vol. 71, No. 2, 03.2011, p. 129-135.

Research output: Contribution to journalArticle

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AU - Liu, Wei-Min

AU - Pai, Man-Hui

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AU - Lin, Jui Yu

AU - Chou, Chih-Ming

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