Downregulated myocardial connexin 43 and suppressed contractility in rabbits subjected to a cholesterol-enriched diet

Lung Chun Lin, Chau Chung Wu, Hung I. Yeh, Long Sheng Lu, Yen Bin Liu, Shien Fong Lin, Yuan Teh Lee

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The effects of hypercholesterolemia on the myocardium per se include electrophysiological and mechanical alterations. Since gap junctions are essential in electromechanical coupling throughout the heart, we examined the correlation between the temporal expression of cardiac connexin 43 (Cx43), contractile function, and conduction velocity in cholesterol-fed rabbits. After a 12-week feeding period, serum cholesterol levels gradually increased (P

Original languageEnglish
Pages (from-to)1224-1237
Number of pages14
JournalLaboratory Investigation
Volume85
Issue number10
DOIs
Publication statusPublished - Oct 2005
Externally publishedYes

Fingerprint

Connexin 43
Down-Regulation
Cholesterol
Diet
Rabbits
Gap Junctions
Hypercholesterolemia
Myocardium
Serum

Keywords

  • Connexin
  • Contractility
  • Echocardiography
  • Gap junction
  • Hypercholesterolemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Downregulated myocardial connexin 43 and suppressed contractility in rabbits subjected to a cholesterol-enriched diet. / Lin, Lung Chun; Wu, Chau Chung; Yeh, Hung I.; Lu, Long Sheng; Liu, Yen Bin; Lin, Shien Fong; Lee, Yuan Teh.

In: Laboratory Investigation, Vol. 85, No. 10, 10.2005, p. 1224-1237.

Research output: Contribution to journalArticle

Lin, Lung Chun ; Wu, Chau Chung ; Yeh, Hung I. ; Lu, Long Sheng ; Liu, Yen Bin ; Lin, Shien Fong ; Lee, Yuan Teh. / Downregulated myocardial connexin 43 and suppressed contractility in rabbits subjected to a cholesterol-enriched diet. In: Laboratory Investigation. 2005 ; Vol. 85, No. 10. pp. 1224-1237.
@article{69a6b50087b14da5bb98eefe91a5d14f,
title = "Downregulated myocardial connexin 43 and suppressed contractility in rabbits subjected to a cholesterol-enriched diet",
abstract = "The effects of hypercholesterolemia on the myocardium per se include electrophysiological and mechanical alterations. Since gap junctions are essential in electromechanical coupling throughout the heart, we examined the correlation between the temporal expression of cardiac connexin 43 (Cx43), contractile function, and conduction velocity in cholesterol-fed rabbits. After a 12-week feeding period, serum cholesterol levels gradually increased (P",
keywords = "Connexin, Contractility, Echocardiography, Gap junction, Hypercholesterolemia",
author = "Lin, {Lung Chun} and Wu, {Chau Chung} and Yeh, {Hung I.} and Lu, {Long Sheng} and Liu, {Yen Bin} and Lin, {Shien Fong} and Lee, {Yuan Teh}",
year = "2005",
month = "10",
doi = "10.1038/labinvest.3700324",
language = "English",
volume = "85",
pages = "1224--1237",
journal = "Laboratory Investigation",
issn = "0023-6837",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - Downregulated myocardial connexin 43 and suppressed contractility in rabbits subjected to a cholesterol-enriched diet

AU - Lin, Lung Chun

AU - Wu, Chau Chung

AU - Yeh, Hung I.

AU - Lu, Long Sheng

AU - Liu, Yen Bin

AU - Lin, Shien Fong

AU - Lee, Yuan Teh

PY - 2005/10

Y1 - 2005/10

N2 - The effects of hypercholesterolemia on the myocardium per se include electrophysiological and mechanical alterations. Since gap junctions are essential in electromechanical coupling throughout the heart, we examined the correlation between the temporal expression of cardiac connexin 43 (Cx43), contractile function, and conduction velocity in cholesterol-fed rabbits. After a 12-week feeding period, serum cholesterol levels gradually increased (P

AB - The effects of hypercholesterolemia on the myocardium per se include electrophysiological and mechanical alterations. Since gap junctions are essential in electromechanical coupling throughout the heart, we examined the correlation between the temporal expression of cardiac connexin 43 (Cx43), contractile function, and conduction velocity in cholesterol-fed rabbits. After a 12-week feeding period, serum cholesterol levels gradually increased (P

KW - Connexin

KW - Contractility

KW - Echocardiography

KW - Gap junction

KW - Hypercholesterolemia

UR - http://www.scopus.com/inward/record.url?scp=25144436058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25144436058&partnerID=8YFLogxK

U2 - 10.1038/labinvest.3700324

DO - 10.1038/labinvest.3700324

M3 - Article

VL - 85

SP - 1224

EP - 1237

JO - Laboratory Investigation

JF - Laboratory Investigation

SN - 0023-6837

IS - 10

ER -