Downregulated myocardial connexin 43 and suppressed contractility in rabbits subjected to a cholesterol-enriched diet

Lung Chun Lin, Chau Chung Wu, Hung I. Yeh, Long Sheng Lu, Yen Bin Liu, Shien Fong Lin, Yuan Teh Lee

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effects of hypercholesterolemia on the myocardium per se include electrophysiological and mechanical alterations. Since gap junctions are essential in electromechanical coupling throughout the heart, we examined the correlation between the temporal expression of cardiac connexin 43 (Cx43), contractile function, and conduction velocity in cholesterol-fed rabbits. After a 12-week feeding period, serum cholesterol levels gradually increased (P

Original languageEnglish
Pages (from-to)1224-1237
Number of pages14
JournalLaboratory Investigation
Volume85
Issue number10
DOIs
Publication statusPublished - Oct 2005
Externally publishedYes

Keywords

  • Connexin
  • Contractility
  • Echocardiography
  • Gap junction
  • Hypercholesterolemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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