Double primary cancers in 2 young sibs, leukemia in another, and dextrocardia in a fourth

Frederick P. Li, Sue McIntosh, Jacqueline Peng‐Whang

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15 Citations (Scopus)


Two brothers developed multiple primary neoplasms in childhood; one had glioblastoma and non‐Hodgkin's lymphoma at age 11 years, and the other brain tumor and acute leukemia at six years. A third brother died with myelogenous leukemia at three years, and a fourth with cyanotic congential heart disease at 11 weeks. Each child aiso had at least one hamartomatous lesion of the skin. The clinical features suggested von Recklinghausen's neurofibromatosis or other inherited cancer syndrome, but laboratory studies identified no markers of susceptibility to familial neoplasia.

Original languageEnglish
Pages (from-to)2633-2636
Number of pages4
Issue number6
Publication statusPublished - Jan 1 1977
Externally publishedYes


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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