Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan

Lai Chu See, Hung-Yi Chiou, Jiahn Shing Lee, Yu-Mei Hsueh, Shu Mei Lin, Ming Chang Tu, Meng Ling Yang, Chien Jen Chen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

This association study was carried out to examine the effect of long-term exposure to ingested arsenic on various types of cataract. A total of 349 residents living in arseniasis-hyperendemic villages of southwestern Taiwan were recruited. Cumulative arsenic exposure was derived from the history of consuming artesian well water and the arsenic level in well water. The Lens Opacities System III was used to classify different types of cataract. The cataract surgery prevalence was 10% for the age group of 50 or more years. Cortical opacity was most common (35%), while nuclear and posterior subcapsular opacities were observed in 24% and 22% of subjects, respectively. Diabetes mellitus was a significant risk factor for all types of cataract. Occupational sunlight exposure was associated with cortical and posterior subcapsular opacities in a dose-response relationship. The cumulative exposure to arsenic from artesian well water and the duration of consuming artesian well water were associated with an increased risk of all types of lens opacity. But statistically significant dose-response relations with the cumulative arsenic exposure and the duration of consuming artesian well water were observed only for posterior subcapsular opacity (P = 0.014 and P = 0.023, respectively) after adjustment for age, sex, diabetes status, and occupational sunlight exposure. It was concluded that there was an increasing prevalence of posterior subcapsular opacity with the increase in exposure to ingested arsenic.

Original languageEnglish
Pages (from-to)1843-1851
Number of pages9
JournalJournal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
Volume42
Issue number12
DOIs
Publication statusPublished - Oct 2007

Fingerprint

dose-response relationship
Opacity
Arsenic
artesian well
arsenic
well water
Water
diabetes
occupational exposure
Medical problems
Lenses
risk factor
Surgery
village
exposure
history

Keywords

  • Cataract
  • Ingested arsenic
  • Posterior subcapsular opacities
  • Prevalence

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Science(all)
  • Environmental Chemistry

Cite this

Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan. / See, Lai Chu; Chiou, Hung-Yi; Lee, Jiahn Shing; Hsueh, Yu-Mei; Lin, Shu Mei; Tu, Ming Chang; Yang, Meng Ling; Chen, Chien Jen.

In: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, Vol. 42, No. 12, 10.2007, p. 1843-1851.

Research output: Contribution to journalArticle

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