Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study

L. I. Hsu, K. H. Hsu, H. Y. Chiou, C. J. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The association of arsenic exposure with Chronic Kidney Disease (CKD) has never been reported in low-to-moderate exposed area in Taiwan. The aim of this study is to examine the dose-response relationship between ingested arsenic and CKD in northeastern Taiwan where well arsenic ranged from undetectable to 3590 μg/L. A total of 6,153 participants were followed 1998–2011. The disease status was ascertained through linkage with National Health Insurance database. Cox regression analysis was used to determine the hazard ratio of the disease associated with arsenic exposure. The dose-response relationship between two arsenic exposure indices and CKD was observed. Hazard ratio was 1.00, 0.92 (95% confidence interval (CI), 0.66–1.28), 1.20 (95%CI, 0.90–1.60), 1.46 (95%CI,1.09–1.95), 1.08 (95%CI,0.80– 1.49) and 1.58 (95%CI,1.14–2.18) in relation to well water arsenic concentration of <10.0, 10.0–24.9, 25.0–49.9, 50.0–99.9, 100.0–499.9 and ≥ 500.0 μg/L (Ptrend:0.0099). Significantly increased CKD risk was observed among people consuming contaminated water with arsenic concentration >50 μg/L.

Original languageEnglish
Title of host publicationArsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
PublisherCRC Press/Balkema
Pages361-362
Number of pages2
ISBN (Print)9781138029415
Publication statusPublished - 2016
Event6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden
Duration: Jun 19 2016Jun 23 2016

Conference

Conference6th International Congress on Arsenic in the Environment, AS 2016
CountrySweden
CityStockholm
Period6/19/166/23/16

Fingerprint

dose-response relationship
Arsenic
Potable water
Drinking Water
arsenic
confidence interval
drinking water
Hazards
hazard
Health insurance
health insurance
well water
Regression analysis
exposure
regression analysis
Water

ASJC Scopus subject areas

  • Pollution
  • Environmental Chemistry

Cite this

Hsu, L. I., Hsu, K. H., Chiou, H. Y., & Chen, C. J. (2016). Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. In Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 (pp. 361-362). CRC Press/Balkema.

Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. / Hsu, L. I.; Hsu, K. H.; Chiou, H. Y.; Chen, C. J.

Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, 2016. p. 361-362.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hsu, LI, Hsu, KH, Chiou, HY & Chen, CJ 2016, Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. in Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, pp. 361-362, 6th International Congress on Arsenic in the Environment, AS 2016, Stockholm, Sweden, 6/19/16.
Hsu LI, Hsu KH, Chiou HY, Chen CJ. Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. In Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema. 2016. p. 361-362
Hsu, L. I. ; Hsu, K. H. ; Chiou, H. Y. ; Chen, C. J. / Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, 2016. pp. 361-362
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abstract = "The association of arsenic exposure with Chronic Kidney Disease (CKD) has never been reported in low-to-moderate exposed area in Taiwan. The aim of this study is to examine the dose-response relationship between ingested arsenic and CKD in northeastern Taiwan where well arsenic ranged from undetectable to 3590 μg/L. A total of 6,153 participants were followed 1998–2011. The disease status was ascertained through linkage with National Health Insurance database. Cox regression analysis was used to determine the hazard ratio of the disease associated with arsenic exposure. The dose-response relationship between two arsenic exposure indices and CKD was observed. Hazard ratio was 1.00, 0.92 (95{\%} confidence interval (CI), 0.66–1.28), 1.20 (95{\%}CI, 0.90–1.60), 1.46 (95{\%}CI,1.09–1.95), 1.08 (95{\%}CI,0.80– 1.49) and 1.58 (95{\%}CI,1.14–2.18) in relation to well water arsenic concentration of <10.0, 10.0–24.9, 25.0–49.9, 50.0–99.9, 100.0–499.9 and ≥ 500.0 μg/L (Ptrend:0.0099). Significantly increased CKD risk was observed among people consuming contaminated water with arsenic concentration >50 μg/L.",
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