Dose distributions of an 192Ir brachytherapy source in different media

C. H. Wu, Y. J. Liao, Y. W Hsueh Liu, S. K. Hung, M. S. Lee, S. M. Hsu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study used MCNPX code to investigate the brachytherapy 192Ir dose distributions in water, bone, and lung tissue and performed radiophotoluminescent glass dosimeter measurements to verify the obtained MCNPX results. The results showed that the dose-rate constant, radial dose function, and anisotropy function in water were highly consistent with data in the literature. However, the lung dose near the source would be overestimated by up to 12%, if the lung tissue is assumed to be water, and, hence, if a tumor is located in the lung, the tumor dose will be overestimated, if the material density is not taken into consideration. In contrast, the lung dose far from the source would be underestimated by up to 30%. Radial dose functions were found to depend not only on the phantom size but also on the material density. The phantom size affects the radial dose function in bone more than those in the other tissues. On the other hand, the anisotropy function in lung tissue was not dependent on the radial distance. Our simulation results could represent valid clinical reference data and be used to improve the accuracy of the doses delivered during brachytherapy applied to patients with lung cancer.

Original languageEnglish
Article number946213
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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Brachytherapy
Lung
Tissue
Anisotropy
Water
Tumors
Bone
Dosimeters
Bone and Bones
Rate constants
Glass
Lung Neoplasms
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Dose distributions of an 192Ir brachytherapy source in different media. / Wu, C. H.; Liao, Y. J.; Liu, Y. W Hsueh; Hung, S. K.; Lee, M. S.; Hsu, S. M.

In: BioMed Research International, Vol. 2014, 946213, 2014.

Research output: Contribution to journalArticle

Wu, C. H. ; Liao, Y. J. ; Liu, Y. W Hsueh ; Hung, S. K. ; Lee, M. S. ; Hsu, S. M. / Dose distributions of an 192Ir brachytherapy source in different media. In: BioMed Research International. 2014 ; Vol. 2014.
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AU - Lee, M. S.

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