Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study

Chueh Hung Wu, Li Sheng Chen, Ming Fang Yen, Yueh Hsia Chiu, Ching Yuan Fann, Hsiu Hsi Chen, Shin Liang Pan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Previous studies on the association between tuberculosis and the risk of developing ischemic stroke have generated inconsistent results. We therefore performed a population-based, propensity score-matched longitudinal follow-up study to investigate whether contracting non-central nervous system (CNS) tuberculosis leads to an increased risk of ischemic stroke. Methods: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 5804 persons with at least three ambulatory visits in 2001 with the principal diagnosis of non-CNS tuberculosis were enrolled in the tuberculosis group. The non-tuberculosis group consisted of 5804, propensity score-matched subjects without tuberculosis. The three-year ischemic stroke-free survival rates for these 2 groups were estimated using the Kaplan-Meier method. The stratified Cox proportional hazards regression was used to estimate the effect of tuberculosis on the occurrence of ischemic stroke. Results: During three-year follow-up, 176 subjects in the tuberculosis group (3.0%) and 207 in the non-tuberculosis group (3.6%) had ischemic stroke. The hazard ratio for developing ischemic stroke in the tuberculosis group was 0.92 compared to the non-tuberculosis group (95% confidence interval: 0.73-1.14, P = 0.4299). Conclusions: Non-CNS tuberculosis does not increase the risk of subsequent ischemic stroke.

Original languageEnglish
Article numbere98158
JournalPLoS One
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 21 2014

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Propensity Score
Neurology
stroke
tuberculosis
nervous system
Nervous System
Tuberculosis
Stroke
Hazards
Population
Logistics
Logistic Models
socioeconomic status
Social Class
Comorbidity
confidence interval
Survival Rate
survival rate
Confidence Intervals
gender

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study. / Wu, Chueh Hung; Chen, Li Sheng; Yen, Ming Fang; Chiu, Yueh Hsia; Fann, Ching Yuan; Chen, Hsiu Hsi; Pan, Shin Liang.

In: PLoS One, Vol. 9, No. 7, e98158, 21.07.2014.

Research output: Contribution to journalArticle

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AU - Fann, Ching Yuan

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AU - Pan, Shin Liang

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