Does multiple sclerosis increase risk of adverse pregnancy outcomes? A population-based study

Y. H. Chen, H. L. Lin, H. C. Lin

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objective: To determine whether maternal multiple sclerosis (MS) is associated with increased risk of adverse pregnancy outcomes in an East Asian country by using a nationwide population-based dataset. Method: This study linked two nationwide population-based datasets, the birth certificate registry and the Taiwan National Health Insurance Research Dataset. We identified a total of 174 women who gave birth from 2001 to 2003, who were diagnosed with MS within the 2 years preceding the index deliveries, together with 1,392 matched women without chronic disease as a comparison cohort. Multivariate logistic regression analyses were performed for estimation. Results: We found that compared with healthy mothers, MS was independently associated with a 2.25-fold risk of preterm birth (95% CI = 1.37-3.70) and a 1.89-fold (95% CI = 1.30-2.76) higher risk of babies small for gestational age, after adjusting for family income and maternal, paternal, and infant characteristics. Mothers with MS were also more likely to have cesarean deliveries. Conclusion: Our study documents increased the risk of adverse pregnancy outcomes for mothers with MS, highlighting a need for more intensive monitoring and obstetric care during pregnancy. Future studies should explore the distinct manifestations and mechanisms of MS in diverse ethnic groups, so more complete information can be provided to affected women concerning pregnancy.

Original languageEnglish
Pages (from-to)606-612
Number of pages7
JournalMultiple Sclerosis
Volume15
Issue number5
DOIs
Publication statusPublished - 2009

Fingerprint

Pregnancy Outcome
Multiple Sclerosis
Mothers
Population
Birth Certificates
Pregnancy
Premature Birth
National Health Programs
Taiwan
Ethnic Groups
Gestational Age
Obstetrics
Registries
Chronic Disease
Logistic Models
Regression Analysis
Parturition
Research
Datasets

Keywords

  • Multiple sclerosis
  • Pregnancy outcome
  • Preterm birth

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Does multiple sclerosis increase risk of adverse pregnancy outcomes? A population-based study. / Chen, Y. H.; Lin, H. L.; Lin, H. C.

In: Multiple Sclerosis, Vol. 15, No. 5, 2009, p. 606-612.

Research output: Contribution to journalArticle

@article{d44c83b24b734aefa4618aa405572b80,
title = "Does multiple sclerosis increase risk of adverse pregnancy outcomes? A population-based study",
abstract = "Objective: To determine whether maternal multiple sclerosis (MS) is associated with increased risk of adverse pregnancy outcomes in an East Asian country by using a nationwide population-based dataset. Method: This study linked two nationwide population-based datasets, the birth certificate registry and the Taiwan National Health Insurance Research Dataset. We identified a total of 174 women who gave birth from 2001 to 2003, who were diagnosed with MS within the 2 years preceding the index deliveries, together with 1,392 matched women without chronic disease as a comparison cohort. Multivariate logistic regression analyses were performed for estimation. Results: We found that compared with healthy mothers, MS was independently associated with a 2.25-fold risk of preterm birth (95{\%} CI = 1.37-3.70) and a 1.89-fold (95{\%} CI = 1.30-2.76) higher risk of babies small for gestational age, after adjusting for family income and maternal, paternal, and infant characteristics. Mothers with MS were also more likely to have cesarean deliveries. Conclusion: Our study documents increased the risk of adverse pregnancy outcomes for mothers with MS, highlighting a need for more intensive monitoring and obstetric care during pregnancy. Future studies should explore the distinct manifestations and mechanisms of MS in diverse ethnic groups, so more complete information can be provided to affected women concerning pregnancy.",
keywords = "Multiple sclerosis, Pregnancy outcome, Preterm birth",
author = "Chen, {Y. H.} and Lin, {H. L.} and Lin, {H. C.}",
year = "2009",
doi = "10.1177/1352458508101937",
language = "English",
volume = "15",
pages = "606--612",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "5",

}

TY - JOUR

T1 - Does multiple sclerosis increase risk of adverse pregnancy outcomes? A population-based study

AU - Chen, Y. H.

AU - Lin, H. L.

AU - Lin, H. C.

PY - 2009

Y1 - 2009

N2 - Objective: To determine whether maternal multiple sclerosis (MS) is associated with increased risk of adverse pregnancy outcomes in an East Asian country by using a nationwide population-based dataset. Method: This study linked two nationwide population-based datasets, the birth certificate registry and the Taiwan National Health Insurance Research Dataset. We identified a total of 174 women who gave birth from 2001 to 2003, who were diagnosed with MS within the 2 years preceding the index deliveries, together with 1,392 matched women without chronic disease as a comparison cohort. Multivariate logistic regression analyses were performed for estimation. Results: We found that compared with healthy mothers, MS was independently associated with a 2.25-fold risk of preterm birth (95% CI = 1.37-3.70) and a 1.89-fold (95% CI = 1.30-2.76) higher risk of babies small for gestational age, after adjusting for family income and maternal, paternal, and infant characteristics. Mothers with MS were also more likely to have cesarean deliveries. Conclusion: Our study documents increased the risk of adverse pregnancy outcomes for mothers with MS, highlighting a need for more intensive monitoring and obstetric care during pregnancy. Future studies should explore the distinct manifestations and mechanisms of MS in diverse ethnic groups, so more complete information can be provided to affected women concerning pregnancy.

AB - Objective: To determine whether maternal multiple sclerosis (MS) is associated with increased risk of adverse pregnancy outcomes in an East Asian country by using a nationwide population-based dataset. Method: This study linked two nationwide population-based datasets, the birth certificate registry and the Taiwan National Health Insurance Research Dataset. We identified a total of 174 women who gave birth from 2001 to 2003, who were diagnosed with MS within the 2 years preceding the index deliveries, together with 1,392 matched women without chronic disease as a comparison cohort. Multivariate logistic regression analyses were performed for estimation. Results: We found that compared with healthy mothers, MS was independently associated with a 2.25-fold risk of preterm birth (95% CI = 1.37-3.70) and a 1.89-fold (95% CI = 1.30-2.76) higher risk of babies small for gestational age, after adjusting for family income and maternal, paternal, and infant characteristics. Mothers with MS were also more likely to have cesarean deliveries. Conclusion: Our study documents increased the risk of adverse pregnancy outcomes for mothers with MS, highlighting a need for more intensive monitoring and obstetric care during pregnancy. Future studies should explore the distinct manifestations and mechanisms of MS in diverse ethnic groups, so more complete information can be provided to affected women concerning pregnancy.

KW - Multiple sclerosis

KW - Pregnancy outcome

KW - Preterm birth

UR - http://www.scopus.com/inward/record.url?scp=65349153697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65349153697&partnerID=8YFLogxK

U2 - 10.1177/1352458508101937

DO - 10.1177/1352458508101937

M3 - Article

C2 - 19318510

AN - SCOPUS:65349153697

VL - 15

SP - 606

EP - 612

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 5

ER -