Does hepatitis C virus infection increase risk for stroke? A population-based cohort study

Chien-Chang Liao, Ta Chen Su, Fung Chang Sung, Wan Hsin Chou, Ta-Liang Chen

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Background: The relationship between hepatitis C virus infection and risk of stroke remains inconsistent. This study evaluates the risk of stroke in association with chronic hepatitis C infection in a longitudinal population-based cohort. Methods: We identified 4,094 adults newly diagnosed with hepatitis C infection in 2002-2004 from the Taiwan National Health Insurance Research Database. Comparison group consisted of 16,376 adults without hepatitis C infection randomly selected from the same dataset, frequency matched by age and sex. Events of stroke from 2002-2008 were ascertained from medical claims (International Classification of Diseases, Ninth Revision, Clinical Modification, ICD-9-CM, codes 430-438). Multivariate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for potential associated factors including HCV infection, age, sex, low-income status, urbanization, cessation of cigarette smoking, alcohol-related illness, obesity, history of chronic diseases and medication use. Findings: During 96,752 person-years of follow-up, there were 1981 newly diagnosed stroke cases. The HRs of stroke associated with medical conditions such as hypertension, diabetes and heart disease were 1.48 (95% CI 1.33 to 1.65), 1.23 (95% CI 1.11 to 1.36) and 1.17 (95% CI 1.06 to 1.30), respectively, after adjustment for covariates. The cumulative risk of stroke for people with hepatitis C and without hepatitis C infections was 2.5% and 1.9%, respectively (p

Original languageEnglish
Article numbere31527
JournalPLoS One
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 20 2012

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Hepatitis C virus
Virus Diseases
cohort studies
stroke
Viruses
Hepacivirus
hepatitis C
Cohort Studies
Stroke
Hepatitis C
confidence interval
Hazards
infection
Confidence Intervals
Health insurance
Population
Infection
International Classification of Diseases
Medical problems
Tobacco Products

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Does hepatitis C virus infection increase risk for stroke? A population-based cohort study. / Liao, Chien-Chang; Su, Ta Chen; Sung, Fung Chang; Chou, Wan Hsin; Chen, Ta-Liang.

In: PLoS One, Vol. 7, No. 2, e31527, 20.02.2012.

Research output: Contribution to journalArticle

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