Does hepatitis C virus affect the reactivation of hepatitis B virus following renal transplantation?

Tzung Hai Yen, Chiu Ching Huang, Hsin Hung Lin, Jeng Yi Huang, Ya Chun Tian, Chih Wei Yang, Mai Szu Wu, Ji Tseng Fang, Chun Chen Yu, Yang Jen Chiang, Sheng Hsieh Chu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background. Hepatitis B virus (HBV) is endemic in Taiwan. Transplantation followed by long-term immunosuppressive medications may precipitate HBV reactivation. Interference of hepatitis C virus (HCV) with HBV gene expression and replication has been confirmed in many studies involving non-transplant populations. This study investigates the incidence of HBV reactivation following renal transplantation and compares the clinical outcome, especially the liver outcome, of patients with or without HCV co-infection. Methods. Fifty-one of 512 renal transplant recipients were positive for hepatitis B surface antigen before surgery, and were followed for 81.6±7.5 (4-120) months. Seventeen of 51 patients acquired HCV before transplantation and six patients acquired HCV after renal transplantation. Results. At the end of this assessment, we had 28 patients who suffered HBV reactivation and another 23 patients who suffered no HBV reactivation. Initially, we found a significant difference of HCV carriage (P

Original languageEnglish
Pages (from-to)1046-1052
Number of pages7
JournalNephrology Dialysis Transplantation
Volume21
Issue number4
DOIs
Publication statusPublished - Apr 2006
Externally publishedYes

Keywords

  • Co-infection
  • HBV
  • HCV
  • Reactivation
  • Renal transplantation

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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  • Cite this

    Yen, T. H., Huang, C. C., Lin, H. H., Huang, J. Y., Tian, Y. C., Yang, C. W., Wu, M. S., Fang, J. T., Yu, C. C., Chiang, Y. J., & Chu, S. H. (2006). Does hepatitis C virus affect the reactivation of hepatitis B virus following renal transplantation? Nephrology Dialysis Transplantation, 21(4), 1046-1052. https://doi.org/10.1093/ndt/gfk023