Does ethnic variability exist in the systemic exposures of oatp1a2 substrates-fexofenadine in taiwanese?

Y. A. Chen, C. H. Juan, K. Y. Hsu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to investigate differences in organic anion transporting polypeptide 1A2 activity among the Taiwanese population via an analysis of 3 pharmacokinetic studies completed in a total of 103 healthy male Taiwanese subjects. The pharmacokinetics of fexofenadine was measured as an indicator of organic anion transporting polypeptide 1A2 activity. Using the Kolmogorov-Smirnov test and quantile plots, the frequency distributions of area under the concentration-time curve and concentration were shown to be tri-modal and to represent 3 pharmacokinetic phenotypes. In a comparison with published data, the mean area under the concentration-time curve of fexofenadine in the Taiwanese subjects was similar to that in American, German, and Indian subjects, but significantly different from that in some Asian populations, including Korean and Japanese ethnic groups. These results suggested that Taiwanese subjects showed genetic variation in fexofenadine pharmacokinetics that was associated with differences in organic anion transporting polypeptide 1A2 activity.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalIndian Journal of Pharmaceutical Sciences
Volume77
Issue number5
Publication statusPublished - Sep 1 2015

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fexofenadine
Pharmacokinetics
Anions
Peptides
North American Indians
Nonparametric Statistics
Ethnic Groups
Population
Phenotype

Keywords

  • Fexofenadine
  • OATP1A2
  • organic anion transporting polypeptide 1A2
  • pharmacokinetics
  • Taiwanese

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Does ethnic variability exist in the systemic exposures of oatp1a2 substrates-fexofenadine in taiwanese? / Chen, Y. A.; Juan, C. H.; Hsu, K. Y.

In: Indian Journal of Pharmaceutical Sciences, Vol. 77, No. 5, 01.09.2015, p. 573-578.

Research output: Contribution to journalArticle

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