DNA single strand breaks in peripheral lymphocytes associated with urinary thiodiglycolic acid levels in polyvinyl chloride workers

Yu Chen Lei, Huei Ting Yang, Yee Chung Ma, Ming Feng Huang, Wushou P. Chang, Tsun Jen Cheng

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The association between vinyl chloride monomer (VCM) exposure and DNA damage has been established. However, the relationship between individual exposure and DNA single strand breaks was limited. Since environmental monitoring may not reflect the actual exposure, a useful marker of exposure is needed to assess the individual exposure. In our previous study, we have found a high correlation between air VCM level and urinary thiodiglycolic acid (TdGA) at the commencement of the next shift. Here, we further used comet assay to evaluate the relationship between urinary TdGA levels and DNA single strand breaks in polyvinyl chloride monomer (PVC) workers. Urinary TdGA levels (n = 26) at the commencement of the following shift were analyzed. Ten of the 26 workers also had personal air sampling for air VCM exposure. Questionnaires were administered to obtain epidemiological information including detailed history of occupation and lifestyles. Workers experiencing air VCM level greater than 5 ppm had higher tail moment and tail intensity (%) than those experiencing VCM exposure between 1 and 5, or

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume561
Issue number1-2
DOIs
Publication statusPublished - Jul 11 2004
Externally publishedYes

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Keywords

  • DNA single strand breaks
  • Urinary thiodiglycolic acid
  • Vinyl chloride monomer

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Genetics

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