DNA polymerase I is not required for replication of linear chromosomes in Streptomyces

Tzu-Wen Huang, Hsiu-Hwei Chen

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Both pol4 (encoding DNA polymerase I; Pol I) and a paralog were deleted from Streptomyces strains. Despite the UV sensitivity and slow growth caused by the ΔpolA mutation, the double mutant was viable. Thus, in contrast to a previous postulate, Pol I and its paralog are not essential for replication of Streptomyces chromosomes. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)755-758
Number of pages4
JournalJournal of Bacteriology
Issue number2
Publication statusPublished - 2008
Externally publishedYes


  • bacterial DNA
  • DNA directed DNA polymerase beta
  • article
  • bacterial chromosome
  • biosynthesis
  • gene deletion
  • gene expression regulation
  • genetics
  • growth, development and aging
  • metabolism
  • microbial viability
  • radiation exposure
  • Streptomyces
  • ultraviolet radiation
  • bacterial growth
  • bacterial strain
  • bacterium mutant
  • chromosome replication
  • gene mutation
  • nonhuman
  • priority journal
  • radiosensitivity
  • Chromosomes, Bacterial
  • DNA Polymerase I
  • DNA, Bacterial
  • Gene Deletion
  • Microbial Viability
  • Mutagenesis, Insertional
  • Ultraviolet Rays


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