DNA mimic proteins: Functions, structures, and bioinformatic analysis

Hao Ching Wang, Chun Han Ho, Kai Cheng Hsu, Jinn Moon Yang, Andrew H J Wang

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

DNA mimic proteins have DNA-like negative surface charge distributions, and they function by occupying the DNA binding sites of DNA binding proteins to prevent these sites from being accessed by DNA. DNA mimic proteins control the activities of a variety of DNA binding proteins and are involved in a wide range of cellular mechanisms such as chromatin assembly, DNA repair, transcription regulation, and gene recombination. However, the sequences and structures of DNA mimic proteins are diverse, making them difficult to predict by bioinformatic search. To date, only a few DNA mimic proteins have been reported. These DNA mimics were not found by searching for functional motifs in their sequences but were revealed only by structural analysis of their charge distribution. This review highlights the biological roles and structures of 16 reported DNA mimic proteins. We also discuss approaches that might be used to discover new DNA mimic proteins.

Original languageEnglish
Pages (from-to)2865-2874
Number of pages10
JournalBiochemistry
Volume53
Issue number18
DOIs
Publication statusPublished - May 13 2014

Fingerprint

Bioinformatics
Computational Biology
DNA
Proteins
DNA-Binding Proteins
Charge distribution
Chromatin Assembly and Disassembly
DNA Repair
Genetic Recombination
Transcription
Surface charge
Structural analysis
Binding Sites
Chromatin
Repair
Genes

ASJC Scopus subject areas

  • Biochemistry

Cite this

DNA mimic proteins : Functions, structures, and bioinformatic analysis. / Wang, Hao Ching; Ho, Chun Han; Hsu, Kai Cheng; Yang, Jinn Moon; Wang, Andrew H J.

In: Biochemistry, Vol. 53, No. 18, 13.05.2014, p. 2865-2874.

Research output: Contribution to journalReview article

Wang, Hao Ching ; Ho, Chun Han ; Hsu, Kai Cheng ; Yang, Jinn Moon ; Wang, Andrew H J. / DNA mimic proteins : Functions, structures, and bioinformatic analysis. In: Biochemistry. 2014 ; Vol. 53, No. 18. pp. 2865-2874.
@article{5a28e12b18494d46bfda70bb9b256acc,
title = "DNA mimic proteins: Functions, structures, and bioinformatic analysis",
abstract = "DNA mimic proteins have DNA-like negative surface charge distributions, and they function by occupying the DNA binding sites of DNA binding proteins to prevent these sites from being accessed by DNA. DNA mimic proteins control the activities of a variety of DNA binding proteins and are involved in a wide range of cellular mechanisms such as chromatin assembly, DNA repair, transcription regulation, and gene recombination. However, the sequences and structures of DNA mimic proteins are diverse, making them difficult to predict by bioinformatic search. To date, only a few DNA mimic proteins have been reported. These DNA mimics were not found by searching for functional motifs in their sequences but were revealed only by structural analysis of their charge distribution. This review highlights the biological roles and structures of 16 reported DNA mimic proteins. We also discuss approaches that might be used to discover new DNA mimic proteins.",
author = "Wang, {Hao Ching} and Ho, {Chun Han} and Hsu, {Kai Cheng} and Yang, {Jinn Moon} and Wang, {Andrew H J}",
year = "2014",
month = "5",
day = "13",
doi = "10.1021/bi5002689",
language = "English",
volume = "53",
pages = "2865--2874",
journal = "Biochemistry",
issn = "0006-2960",
publisher = "American Chemical Society",
number = "18",

}

TY - JOUR

T1 - DNA mimic proteins

T2 - Functions, structures, and bioinformatic analysis

AU - Wang, Hao Ching

AU - Ho, Chun Han

AU - Hsu, Kai Cheng

AU - Yang, Jinn Moon

AU - Wang, Andrew H J

PY - 2014/5/13

Y1 - 2014/5/13

N2 - DNA mimic proteins have DNA-like negative surface charge distributions, and they function by occupying the DNA binding sites of DNA binding proteins to prevent these sites from being accessed by DNA. DNA mimic proteins control the activities of a variety of DNA binding proteins and are involved in a wide range of cellular mechanisms such as chromatin assembly, DNA repair, transcription regulation, and gene recombination. However, the sequences and structures of DNA mimic proteins are diverse, making them difficult to predict by bioinformatic search. To date, only a few DNA mimic proteins have been reported. These DNA mimics were not found by searching for functional motifs in their sequences but were revealed only by structural analysis of their charge distribution. This review highlights the biological roles and structures of 16 reported DNA mimic proteins. We also discuss approaches that might be used to discover new DNA mimic proteins.

AB - DNA mimic proteins have DNA-like negative surface charge distributions, and they function by occupying the DNA binding sites of DNA binding proteins to prevent these sites from being accessed by DNA. DNA mimic proteins control the activities of a variety of DNA binding proteins and are involved in a wide range of cellular mechanisms such as chromatin assembly, DNA repair, transcription regulation, and gene recombination. However, the sequences and structures of DNA mimic proteins are diverse, making them difficult to predict by bioinformatic search. To date, only a few DNA mimic proteins have been reported. These DNA mimics were not found by searching for functional motifs in their sequences but were revealed only by structural analysis of their charge distribution. This review highlights the biological roles and structures of 16 reported DNA mimic proteins. We also discuss approaches that might be used to discover new DNA mimic proteins.

UR - http://www.scopus.com/inward/record.url?scp=84900559770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900559770&partnerID=8YFLogxK

U2 - 10.1021/bi5002689

DO - 10.1021/bi5002689

M3 - Review article

C2 - 24766129

AN - SCOPUS:84900559770

VL - 53

SP - 2865

EP - 2874

JO - Biochemistry

JF - Biochemistry

SN - 0006-2960

IS - 18

ER -