DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

Ching Yu Yen, Hurng Wern Huang, Chih Wen Shu, Ming Feng Hou, Shyng Shiou F Yuan, Hui Ru Wang, Yung Ting Chang, Ammad Ahmad Farooqi, Jen Yang Tang, Hsueh Wei Chang

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Abstract

Epigenetic modifications play important roles in regulating carcinogenesis, and specific epigenetic modifications have emerged as potential tumor markers. Herein, we summarize several types of epigenetic modifications, explore the role played by epigenetic modifications in gene regulation, and describe the patterns of epigenetic modifications in cancers. Since epigenetic modifications have been reported to regulate the Warburg effect in cancers, the roles of epigenetic modifications in sugar metabolism are discussed. In addition, oxidative stress may play an important role in carcinogenesis, and the role of oxidative stress and epigenetic modification in carcinogenesis is addressed. We also discuss the role of epigenetic modifications as therapeutic targets. Finally, the synergistic effects of the combined treatment of epigenetic regulator and anticancer drugs for cancer therapy are described.

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalCancer Letters
Volume373
Issue number2
DOIs
Publication statusPublished - Apr 10 2016

Keywords

  • Acetylation
  • Epigenetic modification
  • Histone
  • Methylation
  • Sugar metabolism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Yen, C. Y., Huang, H. W., Shu, C. W., Hou, M. F., Yuan, S. S. F., Wang, H. R., Chang, Y. T., Farooqi, A. A., Tang, J. Y., & Chang, H. W. (2016). DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers. Cancer Letters, 373(2), 185-192. https://doi.org/10.1016/j.canlet.2016.01.036