DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

Ching Yu Yen, Hurng Wern Huang, Chih Wen Shu, Ming Feng Hou, Shyng Shiou F Yuan, Hui Ru Wang, Yung Ting Chang, Ammad Ahmad Farooqi, Jen Yang Tang, Hsueh Wei Chang

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Epigenetic modifications play important roles in regulating carcinogenesis, and specific epigenetic modifications have emerged as potential tumor markers. Herein, we summarize several types of epigenetic modifications, explore the role played by epigenetic modifications in gene regulation, and describe the patterns of epigenetic modifications in cancers. Since epigenetic modifications have been reported to regulate the Warburg effect in cancers, the roles of epigenetic modifications in sugar metabolism are discussed. In addition, oxidative stress may play an important role in carcinogenesis, and the role of oxidative stress and epigenetic modification in carcinogenesis is addressed. We also discuss the role of epigenetic modifications as therapeutic targets. Finally, the synergistic effects of the combined treatment of epigenetic regulator and anticancer drugs for cancer therapy are described.

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalCancer Letters
Volume373
Issue number2
DOIs
Publication statusPublished - Apr 10 2016

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DNA Methylation
Acetylation
Epigenomics
Histones
Methylation
Neoplasms
Therapeutics
Carcinogenesis
Oxidative Stress
Tumor Biomarkers
Drug Therapy

Keywords

  • Acetylation
  • Epigenetic modification
  • Histone
  • Methylation
  • Sugar metabolism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers. / Yen, Ching Yu; Huang, Hurng Wern; Shu, Chih Wen; Hou, Ming Feng; Yuan, Shyng Shiou F; Wang, Hui Ru; Chang, Yung Ting; Farooqi, Ammad Ahmad; Tang, Jen Yang; Chang, Hsueh Wei.

In: Cancer Letters, Vol. 373, No. 2, 10.04.2016, p. 185-192.

Research output: Contribution to journalArticle

Yen, CY, Huang, HW, Shu, CW, Hou, MF, Yuan, SSF, Wang, HR, Chang, YT, Farooqi, AA, Tang, JY & Chang, HW 2016, 'DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers', Cancer Letters, vol. 373, no. 2, pp. 185-192. https://doi.org/10.1016/j.canlet.2016.01.036
Yen, Ching Yu ; Huang, Hurng Wern ; Shu, Chih Wen ; Hou, Ming Feng ; Yuan, Shyng Shiou F ; Wang, Hui Ru ; Chang, Yung Ting ; Farooqi, Ammad Ahmad ; Tang, Jen Yang ; Chang, Hsueh Wei. / DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers. In: Cancer Letters. 2016 ; Vol. 373, No. 2. pp. 185-192.
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