DNA flow cytometric analysis of chest-wall chondroma and chondrosarcoma

Chih Shiun Shih, Liang Shun Wang, Shyh Sheng Yang, Huei Jyh Fahn

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

DNA flow cytometric analysis was per formed for prediction of malignancy potential, and hence of outcome, in 17 patients aged 29-76 (mean 52) years with cartilaginous tumour of the chest wall. Histologically there were nine chondromas and eight chondrosarcomas. The chondrosarcomas (3 grade I, 4 grade II, 1 grade III) were significantly larger than the chondromas (13.6 ± 7.8 vs 4.2 ± 2.0 cm, p <0.001). DNA flow cytometry was performed on paraffin-embedded blocks of resected tumour. In eight of the 17 tumours (6 chondromas, 1 grade I and 1 grade II chondrosarcoma) measurement of DNA content failed because of low cellularity and severe calcification. Aneuploid DNA content was detected only in three chondrosarcomas (2 grade II, 1 grade III). The synthetic phase fraction was less than 15% in all the studied chondromas, but exceeded 25% in four of six chondrosarcomas. This case series though small, may indicate a trend towards association between higher histologic grading and greater incidence of aneuploidy with higher synthetic phase fraction. Tumour size, histologic grade, DNA ploidy and adequacy of surgical resection are the main influences on prognosis.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalScandinavian Journal of Thoracic and Cardiovascular Surgery
Volume30
Issue number3-4
Publication statusPublished - 1996
Externally publishedYes

Keywords

  • Chondroma
  • Chondrosarcoma
  • DNA flow cytometry

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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