DNA adduct level in lung tissue may act as a risk biomarker of lung cancer

Y. W. Cheng, C. Y. Chen, P. Lin, C. P. Chen, K. H. Huang, T. S. Lin, M. H. Wu, H. Lee

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Lung cancer is a leading cause of mortality in Taiwan. We hypothesised that high susceptibility to DNA damage in the target organ acts as a risk biomarker for the development of lung cancer. To verify this hypothesis, the aromatic/hydrophobic DNA adduct levels of non-tumorous adjacent lung tissues from 73 primary lung cancer patients and 33 non-cancer controls were evaluated by 32P-postlabelling assay. Wilcoxon rank sum test showed that DNA adduct levels in lung cancer patients (49.58±33.39 adducts/108 nucleotides) were significantly higher than those in non-cancer controls (18.00±15.33 adducts/108 nucleotides, P48.66 adducts/108 nucleotides) had an approximately 25-fold risk of lung cancer compared with persons with low DNA adduct levels (≤48.66 adducts/108 nucleotides). In conclusion, DNA adduct levels in lung tissue may be a more reliable lung cancer susceptibility biomarker than DNA adduct levels in leucocytes. In addition, higher susceptibility to DNA damage in lung cancer patients may partly play a role in the development of lung cancer. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1381-1388
Number of pages8
JournalEuropean Journal of Cancer
Volume36
Issue number11
DOIs
Publication statusPublished - Jul 2000
Externally publishedYes

Keywords

  • Aromatic/hydrophobic DNA adducts
  • Lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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