Diterpene glycosides and polyketides from xylotumulus gibbisporus

Ya Chih Chang, Chung Kuang Lu, Yin Ru Chiang, Guei Jane Wang, Yu Ming Ju, Yueh Hsiung Kuo, Zong-Huei Li

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Four new tetracyclic diterpene glycosides, namely, sordarins C-F (1-4), and three new γ-lactone polyketides, namely, xylogiblactones A-C (5-7), along with sordarin were isolated from the ethyl acetate extracts of the fermented broths of Xylotumulus gibbisporus YMJ863. The structures of 1-7 were elucidated on the basis of spectroscopic data analyses. The configurations of 1-4 were deduced by NOESY, molecular modeling, and comparison with the literature. The relative configurations of 5-7 were deduced by X-ray crystallographic analysis of 5. Compounds 1-5 and sordarin were evaluated in an antifungal assay using Candida albicans ATCC 18804, C. albicans ATCC MYA-2876, and Saccharomyces cerevisiae ATCC 2345, and only sordarin exhibited significant antifungal activities against these fungal strains, with MIC values of 64.0, 32.0, and 32.0 μg/mL, respectively. The effect of compounds 1-7 and sordarin on the inhibition of NO production in lipopolysaccharide-activated murine macrophages was also evaluated. Compounds 2 and sordarin inhibited NO production with IC50 values of 327.2 ± 46.6 and 157.1 ± 24.1 μM, respectively.

Original languageEnglish
Pages (from-to)751-757
Number of pages7
JournalJournal of Natural Products
Volume77
Issue number4
DOIs
Publication statusPublished - Apr 25 2014

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

Fingerprint Dive into the research topics of 'Diterpene glycosides and polyketides from xylotumulus gibbisporus'. Together they form a unique fingerprint.

  • Cite this

    Chang, Y. C., Lu, C. K., Chiang, Y. R., Wang, G. J., Ju, Y. M., Kuo, Y. H., & Li, Z-H. (2014). Diterpene glycosides and polyketides from xylotumulus gibbisporus. Journal of Natural Products, 77(4), 751-757. https://doi.org/10.1021/np400523k