Distribution of HLA-DQB1 alleles in patients with Kleine-Levin syndrome

Chi Jung Huang; Hung Tsai Liao; Geng Chang Yeh; Kun Long Hung

doi:10.1016/j.jocn.2011.08.020

Distribution of HLA-DQB1 alleles in patients with Kleine-Levin syndrome

Chi Jung Huang, Hung Tsai Liao, Geng Chang Yeh, Kun Long Hung

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurrent episodes of hypersomnia, cognitive or behavior disturbances, compulsive eating behavior, and hypersexuality. The etiology of KLS remains unknown even though its clinical symptoms suggest an underlying autoimmune process. In this study, we analyzed the human leukocyte antigen (HLA) typing alleles in Taiwanese patients with KLS using the polymerase chain reaction sequence-specific priming technique. We report that an immunoresponsive HLA-DQB1, DQB10602, was detected in significant quantities in patients with KLS (three of 12, p = 0.046) and could elevate the risk of KLS (odds ratio, 1.143; 95% confidence interval, 0.0982-1.329). In conclusion, an identification of genomic susceptibility to KLS will be helpful in determining the immunospecific targeted therapies for patients with KLS.

Original language	English
Pages (from-to)	628-630
Number of pages	3
Journal	Journal of Clinical Neuroscience
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.jocn.2011.08.020
Publication status	Published - Apr 2012

Keywords

HLA typing
Hypersomnia
Kleine-Levin syndrome (KLS)

ASJC Scopus subject areas

Clinical Neurology
Neurology
Physiology (medical)

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title = "Distribution of HLA-DQB1 alleles in patients with Kleine-Levin syndrome",

abstract = "Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurrent episodes of hypersomnia, cognitive or behavior disturbances, compulsive eating behavior, and hypersexuality. The etiology of KLS remains unknown even though its clinical symptoms suggest an underlying autoimmune process. In this study, we analyzed the human leukocyte antigen (HLA) typing alleles in Taiwanese patients with KLS using the polymerase chain reaction sequence-specific priming technique. We report that an immunoresponsive HLA-DQB1, DQB10602, was detected in significant quantities in patients with KLS (three of 12, p = 0.046) and could elevate the risk of KLS (odds ratio, 1.143; 95% confidence interval, 0.0982-1.329). In conclusion, an identification of genomic susceptibility to KLS will be helpful in determining the immunospecific targeted therapies for patients with KLS.",

keywords = "HLA typing, Hypersomnia, Kleine-Levin syndrome (KLS)",

author = "Huang, {Chi Jung} and Liao, {Hung Tsai} and Yeh, {Geng Chang} and Hung, {Kun Long}",

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AU - Liao, Hung Tsai

AU - Yeh, Geng Chang

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AB - Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurrent episodes of hypersomnia, cognitive or behavior disturbances, compulsive eating behavior, and hypersexuality. The etiology of KLS remains unknown even though its clinical symptoms suggest an underlying autoimmune process. In this study, we analyzed the human leukocyte antigen (HLA) typing alleles in Taiwanese patients with KLS using the polymerase chain reaction sequence-specific priming technique. We report that an immunoresponsive HLA-DQB1, DQB10602, was detected in significant quantities in patients with KLS (three of 12, p = 0.046) and could elevate the risk of KLS (odds ratio, 1.143; 95% confidence interval, 0.0982-1.329). In conclusion, an identification of genomic susceptibility to KLS will be helpful in determining the immunospecific targeted therapies for patients with KLS.

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