TY - JOUR
T1 - Distribution of HLA-DQB1 alleles in patients with Kleine-Levin syndrome
AU - Huang, Chi Jung
AU - Liao, Hung Tsai
AU - Yeh, Geng Chang
AU - Hung, Kun Long
N1 - Funding Information:
We thank all of the participants involved in this study. We also thank Ms. Chin-Lin Shin, a Pediatric EEG technician at Cathay General Hospital, for collecting the samples and documents. This study was supported by grants of 94CGH-TMU-8 (from Cathay General Hospital and Taipei Medical University) and CMRI-9611 (from Cathay General Hospital).
PY - 2012/4
Y1 - 2012/4
N2 - Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurrent episodes of hypersomnia, cognitive or behavior disturbances, compulsive eating behavior, and hypersexuality. The etiology of KLS remains unknown even though its clinical symptoms suggest an underlying autoimmune process. In this study, we analyzed the human leukocyte antigen (HLA) typing alleles in Taiwanese patients with KLS using the polymerase chain reaction sequence-specific priming technique. We report that an immunoresponsive HLA-DQB1, DQB10602, was detected in significant quantities in patients with KLS (three of 12, p = 0.046) and could elevate the risk of KLS (odds ratio, 1.143; 95% confidence interval, 0.0982-1.329). In conclusion, an identification of genomic susceptibility to KLS will be helpful in determining the immunospecific targeted therapies for patients with KLS.
AB - Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurrent episodes of hypersomnia, cognitive or behavior disturbances, compulsive eating behavior, and hypersexuality. The etiology of KLS remains unknown even though its clinical symptoms suggest an underlying autoimmune process. In this study, we analyzed the human leukocyte antigen (HLA) typing alleles in Taiwanese patients with KLS using the polymerase chain reaction sequence-specific priming technique. We report that an immunoresponsive HLA-DQB1, DQB10602, was detected in significant quantities in patients with KLS (three of 12, p = 0.046) and could elevate the risk of KLS (odds ratio, 1.143; 95% confidence interval, 0.0982-1.329). In conclusion, an identification of genomic susceptibility to KLS will be helpful in determining the immunospecific targeted therapies for patients with KLS.
KW - HLA typing
KW - Hypersomnia
KW - Kleine-Levin syndrome (KLS)
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U2 - 10.1016/j.jocn.2011.08.020
DO - 10.1016/j.jocn.2011.08.020
M3 - Article
C2 - 22285112
AN - SCOPUS:84862826910
VL - 19
SP - 628
EP - 630
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
SN - 0967-5868
IS - 4
ER -