Distribution and effects of DDT in the pregnant rabbit

Michael M. Hart, Jacqueline Whang-Peng, Susan M. Sieber, Sergio Fabro, Richard H. Adamson

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

1. After administration of p, p'-DDT to pregnant rabbits DDT and its metabolites are found in high concn. in both the foetus and the organs of the maternal rabbit which regulate the foetal environment. 2. p.p''-DDT does not rapidly leave the foetal tissue, as whole body levels at day 26 (17 days after DDT dosing) are higher than those in foetal plasma; foetal whole body levels are also higher than those found in placenta or maternal plasma, and half of those of maternal liver. 3. p.p'-DDT treatment of pregnant rabbits at doses of 10 and 50 mg/kg caused an increased incidence of prematurity, an increase in the number of foetal resorptions and a decrease in foetal weight. 4. These doses of DDT did not increase the incidence of chromosomal aberrations in the maternal or foetal tissue and exposure in vitro to levels as high as 100 μg/ml caused no abnormalities.

Original languageEnglish
Pages (from-to)567-574
Number of pages8
JournalXenobiotica
Volume2
Issue number6
DOIs
Publication statusPublished - Jan 1 1972
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Biochemistry, Genetics and Molecular Biology(all)

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    Hart, M. M., Whang-Peng, J., Sieber, S. M., Fabro, S., & Adamson, R. H. (1972). Distribution and effects of DDT in the pregnant rabbit. Xenobiotica, 2(6), 567-574. https://doi.org/10.3109/00498257209111084