Distinguishing bipolar II depression from unipolar major depressive disorder

Differences in heart rate variability

Hsin An Chang, Chuan Chia Chang, Terry B.J. Kuo, San Yuan Huang

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives. Bipolar II (BPII) depression is commonly misdiagnosed as unipolar depression (UD); however, an objective and reliable tool to differentiate between these disorders is lacking. Whether cardiac autonomic function can be used as a biomarker to distinguish BPII from UD is unknown. Methods. We recruited 116 and 591 physically healthy patients with BPII depression and UD, respectively, and 421 healthy volunteers aged 20-65 years. Interviewer and self-reported measures of depression/anxiety severity were obtained. Cardiac autonomic function was evaluated by heart rate variability (HRV) and frequency-domain indices of HRV. Results. Patients with BPII depression exhibited significantly lower mean R-R intervals, variance (total HRV), low frequency (LF)-HRV, and high frequency (HF)-HRV but higher LF/HF ratio compared to those with UD. The significant differences remained after adjusting for age. Compared to the controls, the patients with BPII depression showed cardiac sympathetic excitation with reciprocal vagal impairment, whereas the UD patients showed only vagal impairment. Depression severity independently contributed to decreased HRV and vagal tone in both the patients with BPII depression and UD, but increased sympathetic tone only in those with BPII depression. Conclusions. HRV may aid in the differential diagnosis of BPII depression and UD as an adjunct to diagnostic interviews.

Original languageEnglish
Pages (from-to)351-360
Number of pages10
JournalWorld Journal of Biological Psychiatry
Volume16
Issue number5
DOIs
Publication statusPublished - Aug 1 2015
Externally publishedYes

Fingerprint

Major Depressive Disorder
Depressive Disorder
Bipolar Disorder
Heart Rate
Interviews
Depression
Diagnostic Errors
Healthy Volunteers
Differential Diagnosis
Anxiety
Biomarkers

Keywords

  • Bipolar II depression
  • Cardiac autonomic function
  • Differentiation
  • Heart rate variability
  • Unipolar depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Distinguishing bipolar II depression from unipolar major depressive disorder : Differences in heart rate variability. / Chang, Hsin An; Chang, Chuan Chia; Kuo, Terry B.J.; Huang, San Yuan.

In: World Journal of Biological Psychiatry, Vol. 16, No. 5, 01.08.2015, p. 351-360.

Research output: Contribution to journalArticle

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