Distinct clinicopathological features and prognosis of emerging young-female breast cancer in an east Asian country: A nationwide cancer registry-based study

Ching Hung Lin, Po Ya Chuang, Chun Ju Chiang, Yen Shen Lu, Ann Lii Cheng, Wen Hung Kuo, Chiun Sheng Huang, Mei Shu Lai, San Lin You, Chao Hsiun Tang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background. Arapid surge of young-female breast cancer (YFBC) has been observed in Taiwan and other East Asian countries. We recently reported that these cases of YFBC, in contrast to their Western counterparts, are predominantly luminal A subtype. YFBC in Asia may have distinct clinicopathological features and out comes. Methods. Data collected prospectively by participating hospitals were retrieved from the Taiwan Cancer Database. A total of 15,881 women with newly diagnosed stage I-III breast cancer in 2002-2006 were included. The age at diagnosis was categorized into nine 5-year groups (from <30 years to ≥ 65 years). Clinicopathological variables and patient disease-free survival (DFS) were compared by age group. Results. The rates of stage I, estrogen receptor-positive (ER+), and progesterone receptor-positive breast cancer were higher in the younger patients (<50 years) than in the older patients (≥ 50 years). Univariate analysis showed that the 40-44 and 45-49 age groups were significantly associated with longer DFS than the other age groups. In the ER+ subgroup, multivariate analysis consistently showed that the 40-44 age group was significantly associated with longer DFS than the other age groups except for the 45-49 age group. In contrast, multivariate analysis of the ER-negative subgroup revealed no significant difference of DFS between the 40-44 age group and other age groups. Conclusion. Emerging YFBC in Taiwan is uniquely associated with favorable pathological features and better outcomes and should not be regarded as the mirror image of its Western counterpart.

Original languageEnglish
Pages (from-to)583-591
Number of pages9
JournalOncologist
Volume19
Issue number6
DOIs
Publication statusPublished - 2014

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Registries
Age Groups
Breast Neoplasms
Disease-Free Survival
Neoplasms
Taiwan
Multivariate Analysis
Progesterone Receptors
Estrogen Receptors
Databases

Keywords

  • Asia
  • Breast cancer
  • Estrogen
  • Young

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Distinct clinicopathological features and prognosis of emerging young-female breast cancer in an east Asian country : A nationwide cancer registry-based study. / Lin, Ching Hung; Chuang, Po Ya; Chiang, Chun Ju; Lu, Yen Shen; Cheng, Ann Lii; Kuo, Wen Hung; Huang, Chiun Sheng; Lai, Mei Shu; You, San Lin; Tang, Chao Hsiun.

In: Oncologist, Vol. 19, No. 6, 2014, p. 583-591.

Research output: Contribution to journalArticle

Lin, Ching Hung ; Chuang, Po Ya ; Chiang, Chun Ju ; Lu, Yen Shen ; Cheng, Ann Lii ; Kuo, Wen Hung ; Huang, Chiun Sheng ; Lai, Mei Shu ; You, San Lin ; Tang, Chao Hsiun. / Distinct clinicopathological features and prognosis of emerging young-female breast cancer in an east Asian country : A nationwide cancer registry-based study. In: Oncologist. 2014 ; Vol. 19, No. 6. pp. 583-591.
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