Dissemination of Proteus mirabilis isolates harboring CTX-M-14 and CTX-M-3 β-lactamases at 2 hospitals in Taiwan

Lii Tzu Wu, Hwa Jen Wu, Jing Gung Chung, Yin Ching Chuang, Kuo Chen Cheng, Wen-Liang Yu

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20 Citations (Scopus)

Abstract

From February to June 2003, 111 clinical isolates of Proteus mirabilis were mainly isolated from patients with respiratory or urinary tract infections hospitalized at 3 district hospitals (A, B, C) in central Taiwan. Among them, 34 (30.6%) strains, isolated within 2 hospitals (A and B), exhibited nonsusceptibility to cefotaxime with significant reduction of MIC (≥3 log2 dilution) by the effect of clavulanic acid, which confirmed the phenotype of extended-spectrum β-lactamases (ESBLs). These ESBL producers were coresistant to gentamicin, isepamicin, and amikacin, but remained susceptible to ceftazidime (MIC, ≤0.5 μg/mL) and meropenem (MIC,

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalDiagnostic Microbiology and Infectious Disease
Volume54
Issue number2
DOIs
Publication statusPublished - Feb 2006

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Keywords

  • β-Lactamases
  • CTX-M
  • Proteus mirabilis

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Virology
  • Parasitology
  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology

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