Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Wen Ying Liao; Chung Chi Hsu; Tze Sian Chan; Chia Jui Yen; Wei Yu Chen; Hung Wei Pan; Kelvin K. Tsai

doi:10.1016/j.stemcr.2020.02.003

Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Wen Ying Liao, Chung Chi Hsu, Tze Sian Chan, Chia Jui Yen, Wei Yu Chen, Hung Wei Pan, Kelvin K. Tsai

Research output: Contribution to journal › Article

Abstract

In this article, Tsai and colleagues investigated the Wnt and stemness heterogeneity in HCC and identified a novel subset of Wnt-activity^high “superpotent cancer stem cells” (spCSCs). The existence of spCSCs is independent of β-catenin mutations and its proportion correlates with poor prognosis in patients with HCC. Mechanistically, spCSCs are positively regulated by the Wnt-ASPM-DVL1 signaling axis through protein-protein interactions.

Original language	English
Pages (from-to)	462-477
Number of pages	16
Journal	Stem Cell Reports
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/j.stemcr.2020.02.003
Publication status	Published - Mar 10 2020

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Keywords

ASPM
cancer stem cells
Dishevelled-1
hepatocellular carcinoma
heterogeneity
prognostic marker
ubiquitin ligase
Wnt

ASJC Scopus subject areas

Biochemistry
Genetics
Developmental Biology
Cell Biology

Cite this

Liao, W. Y., Hsu, C. C., Chan, T. S., Yen, C. J., Chen, W. Y., Pan, H. W., & Tsai, K. K. (2020). Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma. Stem Cell Reports, 14(3), 462-477. https://doi.org/10.1016/j.stemcr.2020.02.003

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AU - Chen, Wei Yu

AU - Pan, Hung Wei

AU - Tsai, Kelvin K.

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10.1016/j.stemcr.2020.02.003