Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma

Wen Ying Liao, Chung Chi Hsu, Tze Sian Chan, Chia Jui Yen, Wei Yu Chen, Hung Wei Pan, Kelvin K. Tsai

Research output: Contribution to journalArticle


In this article, Tsai and colleagues investigated the Wnt and stemness heterogeneity in HCC and identified a novel subset of Wnt-activityhigh “superpotent cancer stem cells” (spCSCs). The existence of spCSCs is independent of β-catenin mutations and its proportion correlates with poor prognosis in patients with HCC. Mechanistically, spCSCs are positively regulated by the Wnt-ASPM-DVL1 signaling axis through protein-protein interactions.

Original languageEnglish
Pages (from-to)462-477
Number of pages16
JournalStem Cell Reports
Issue number3
Publication statusPublished - Mar 10 2020



  • ASPM
  • cancer stem cells
  • Dishevelled-1
  • hepatocellular carcinoma
  • heterogeneity
  • prognostic marker
  • ubiquitin ligase
  • Wnt

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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