@article{7539b16ea2574beb9bca937c899c4566,
title = "Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma",
abstract = "In this article, Tsai and colleagues investigated the Wnt and stemness heterogeneity in HCC and identified a novel subset of Wnt-activityhigh “superpotent cancer stem cells” (spCSCs). The existence of spCSCs is independent of β-catenin mutations and its proportion correlates with poor prognosis in patients with HCC. Mechanistically, spCSCs are positively regulated by the Wnt-ASPM-DVL1 signaling axis through protein-protein interactions.",
keywords = "ASPM, cancer stem cells, Dishevelled-1, hepatocellular carcinoma, heterogeneity, prognostic marker, ubiquitin ligase, Wnt",
author = "Liao, {Wen Ying} and Hsu, {Chung Chi} and Chan, {Tze Sian} and Yen, {Chia Jui} and Chen, {Wei Yu} and Pan, {Hung Wei} and Tsai, {Kelvin K.}",
note = "Funding Information: We thank C.-J.Y. for providing us with human HCC tissues. We thank H.-W.P. for providing us with primary HCC cells. This work was supported in part by Ministry of Science and Technology, Taiwan ( MOST106-2314-B-038-089-MY3 , MOST108-2314-B-038-105-MY3 , and MOST108-2314-B-038-026 to K.K.T.; MOST 107-2314-B-038-103 to T.-S.C.), Taipei Medical University ( DP2-107-21121-C-04 , DP2-107-21121-01-GT-02 , 108-TMU-WFH-11 , and 108-TMU-WFH-21 to K.K.T.), Wan Fang Hospital , Chi Mei Medical Center , and Hualien Tzu-Chi Hospital Joint Cancer Center Grant, Ministry of Health and Welfare ( MOHW108-TDU-B-212-124020 to K.K.T.), and TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan (K.K.T.). Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = mar,
day = "10",
doi = "10.1016/j.stemcr.2020.02.003",
language = "English",
volume = "14",
pages = "462--477",
journal = "Stem Cell Reports",
issn = "2213-6711",
publisher = "Cell Press",
number = "3",
}
