Discrepant MR spectroscopic and perfusion imaging results in a case of malignant transformation of cerebral glioma

Wen Chau Wu, Cheng Yu Chen, Hsiao Wen Chung, Chun Jung Juan, Chun Jen Hsueh, Hong Wei Gao

Research output: Contribution to journalArticle

14 Citations (Scopus)


We present serial MR perfusion and spectroscopic findings of a pathologically proved low grade glioma, which evolved into glioblastoma multiforme in 2 years in a 24-year-old man. The initial MR imaging studies, including enhanced conventional T1-weighted and perfusion imaging, were characteristic of a benign glioma with the only exception being that multi-voxel proton MR spectroscopy showed malignant features with a high choline:phosphocreatine ratio. Postoperative follow-up MR imaging revealed findings consistent with malignant glioma, with increased angiogenesis on perfusion images and heterogeneous enhancement on contrast-enhanced T1-weighted images that were further confirmed by second surgery. We suggest conducting close MR imaging follow-up of patients with glioma who have discrepant MR spectroscopic and perfusion results after treatment.

Original languageEnglish
Pages (from-to)1775-1778
Number of pages4
JournalAmerican Journal of Neuroradiology
Issue number10
Publication statusPublished - Nov 2002
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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