Discrepancy of the effects of zinc supplementation on the prevention of radiotherapy-induced mucositis between patients with nasopharyngeal carcinoma and those with oral cancers: Subgroup analysis of a double-blind, randomized study

Yong-Song Lin, Li Ching Lin, Shih Wei Lin, Chun Ping Chang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The purpose of this study was to determine the effect of zinc supplementation on radiation-induced mucositis in patients with nasopharyngeal carcinoma (NPC) and those with oral cancers (OC). A total of 100 patients with head and neck cancers engaged in a randomized double blind study. All participants were placed into two randomized groups (experimental and control). The experimental group received a standard dose of zinc supplements, and the control group was given a placebo. Subgroup analyses were performed between 40 NPC and 43 OC patients. It was found that patients with OC in the control group developed Grade 2 and Grade 3 mucositis sooner than those in the experimental group. However, the benefits were not found to extend to patients with NPC. The results indicated that zinc supplementation prescribed in conjunction with radiotherapy postponed the development of severe mucositis solely for patients with OC. The pretreatment oral mucosa condition and areca chewing habit might account for such discrepancy.

Original languageEnglish
Pages (from-to)682-691
Number of pages10
JournalNutrition and Cancer
Volume62
Issue number5
DOIs
Publication statusPublished - 2010

Fingerprint

Mucositis
Mouth Neoplasms
Double-Blind Method
Zinc
Radiotherapy
Control Groups
Areca
Mastication
Mouth Mucosa
Head and Neck Neoplasms
Habits
Nasopharyngeal carcinoma
Placebos
Radiation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research
  • Medicine(all)

Cite this

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abstract = "The purpose of this study was to determine the effect of zinc supplementation on radiation-induced mucositis in patients with nasopharyngeal carcinoma (NPC) and those with oral cancers (OC). A total of 100 patients with head and neck cancers engaged in a randomized double blind study. All participants were placed into two randomized groups (experimental and control). The experimental group received a standard dose of zinc supplements, and the control group was given a placebo. Subgroup analyses were performed between 40 NPC and 43 OC patients. It was found that patients with OC in the control group developed Grade 2 and Grade 3 mucositis sooner than those in the experimental group. However, the benefits were not found to extend to patients with NPC. The results indicated that zinc supplementation prescribed in conjunction with radiotherapy postponed the development of severe mucositis solely for patients with OC. The pretreatment oral mucosa condition and areca chewing habit might account for such discrepancy.",
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AU - Lin, Li Ching

AU - Lin, Shih Wei

AU - Chang, Chun Ping

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