Discovery of the novel HLA-DRB1*16: 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16

K. L. Yang; S. K. Lee; R. H. Kao; C. L. Lin; P. Y. Lin

doi:10.1111/j.1744-313X.2012.01111.x

Discovery of the novel HLA-DRB116: 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB116:16

K. L. Yang, S. K. Lee, R. H. Kao, C. L. Lin, P. Y. Lin

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.

Original language	English
Pages (from-to)	445-447
Number of pages	3
Journal	International Journal of Immunogenetics
Volume	39
Issue number	5
DOIs	https://doi.org/10.1111/j.1744-313X.2012.01111.x
Publication status	Published - Oct 1 2012
Externally published	Yes

ASJC Scopus subject areas

Genetics
Molecular Biology
Immunology
Genetics(clinical)

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Discovery of the novel HLA-DRB1*16 : 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16. / Yang, K. L.; Lee, S. K.; Kao, R. H.; Lin, C. L.; Lin, P. Y.

In: International Journal of Immunogenetics, Vol. 39, No. 5, 01.10.2012, p. 445-447.

Research output: Contribution to journal › Article › peer-review

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abstract = "We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.",

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