Discovery of the novel HLA-DRB1*16: 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16

K. L. Yang; S. K. Lee; R. H. Kao; C. L. Lin; P. Y. Lin

doi:10.1111/j.1744-313X.2012.01111.x

Discovery of the novel HLA-DRB116: 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB116:16

K. L. Yang, S. K. Lee, R. H. Kao, C. L. Lin, P. Y. Lin

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.

Original language	English
Pages (from-to)	445-447
Number of pages	3
Journal	International Journal of Immunogenetics
Volume	39
Issue number	5
DOIs	https://doi.org/10.1111/j.1744-313X.2012.01111.x
Publication status	Published - Oct 1 2012
Externally published	Yes

ASJC Scopus subject areas

Genetics
Molecular Biology
Immunology
Genetics(clinical)

Access to Document

10.1111/j.1744-313X.2012.01111.x

Cite this

Discovery of the novel HLA-DRB1*16 : 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16. / Yang, K. L.; Lee, S. K.; Kao, R. H.; Lin, C. L.; Lin, P. Y.

In: International Journal of Immunogenetics, Vol. 39, No. 5, 01.10.2012, p. 445-447.

Research output: Contribution to journal › Article › peer-review

@article{ee10147a7bdb4c0fba805c7986854d35,

title = "Discovery of the novel HLA-DRB1*16: 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16",

abstract = "We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.",

author = "Yang, {K. L.} and Lee, {S. K.} and Kao, {R. H.} and Lin, {C. L.} and Lin, {P. Y.}",

year = "2012",

month = oct,

day = "1",

doi = "10.1111/j.1744-313X.2012.01111.x",

language = "English",

volume = "39",

pages = "445--447",

journal = "Journal of Immunogenetics",

issn = "1744-3121",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Discovery of the novel HLA-DRB1*16

T2 - 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16

AU - Yang, K. L.

AU - Lee, S. K.

AU - Kao, R. H.

AU - Lin, C. L.

AU - Lin, P. Y.

PY - 2012/10/1

Y1 - 2012/10/1

N2 - We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.

AB - We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.

UR - http://www.scopus.com/inward/record.url?scp=84865860602&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865860602&partnerID=8YFLogxK

U2 - 10.1111/j.1744-313X.2012.01111.x

DO - 10.1111/j.1744-313X.2012.01111.x

M3 - Article

C2 - 22486893

AN - SCOPUS:84865860602

VL - 39

SP - 445

EP - 447

JO - Journal of Immunogenetics

JF - Journal of Immunogenetics

SN - 1744-3121

IS - 5

ER -

Discovery of the novel HLA-DRB116: 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB116:16

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this