Abstract
We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.
| Original language | English |
|---|---|
| Pages (from-to) | 445-447 |
| Number of pages | 3 |
| Journal | International Journal of Immunogenetics |
| Volume | 39 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1 2012 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Immunology
- Genetics(clinical)
Cite this
Discovery of the novel HLA-DRB1*16 : 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16. / Yang, K. L.; Lee, S. K.; Kao, R. H.; Lin, C. L.; Lin, P. Y.
In: International Journal of Immunogenetics, Vol. 39, No. 5, 01.10.2012, p. 445-447.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Discovery of the novel HLA-DRB1*16
T2 - 16 allele in a Taiwanese unrelated bone marrow stem cell donor by a sequence-based typing method and the probable haplotype associated with DRB1*16:16
AU - Yang, K. L.
AU - Lee, S. K.
AU - Kao, R. H.
AU - Lin, C. L.
AU - Lin, P. Y.
PY - 2012/10/1
Y1 - 2012/10/1
N2 - We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.
AB - We report here a de novo HLA-DRB1 allele, DRB1*16:16, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing (SBT) method. In exon 2, the DNA sequence of DRB1*16:16 is identical to the sequence of DRB1*16:02:01 except the nucleotides at positions 258 (C→T), 260 (C→A) and 261 (T→G). The nucleotide substitution produced an amino acid replacement at residue 58 (A→E). The formation of DRB1*16:16 was probably generated by a DNA sequence recombination event involving DRB1*11:01:01 and DRB1*16:02:01. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*16:16 may be deduced as A*02-B*38-DRB1*16:16.
UR - http://www.scopus.com/inward/record.url?scp=84865860602&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865860602&partnerID=8YFLogxK
U2 - 10.1111/j.1744-313X.2012.01111.x
DO - 10.1111/j.1744-313X.2012.01111.x
M3 - Article
C2 - 22486893
AN - SCOPUS:84865860602
VL - 39
SP - 445
EP - 447
JO - International Journal of Immunogenetics
JF - International Journal of Immunogenetics
SN - 1744-3121
IS - 5
ER -