Discovery of the novel HLA-DRB1*09: 01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08

K. L. Yang, S. K. Lee, S. Y. Yang, R. H. Kao, C. L. Lin, P. Y. Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(C→T) (GCC→GCT at codon 58). We hypothesize DRB1*09:01:08 was probably derived from DRB1*09:01:02 via a nucleotide point mutation event. The plausible HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08 was deduced as A*02:07-B*46:01-DRB1*09:01:08.

Original languageEnglish
Pages (from-to)149-150
Number of pages2
JournalInternational Journal of Immunogenetics
Volume40
Issue number2
DOIs
Publication statusPublished - Apr 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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