Discovery of the novel HLA-DRB1*04: 05:14 allele in a Taiwanese unrelated haematopoietic stem cell donor by a sequence-based typing method

K. L. Yang, S. K. Lee, R. H. Kao, C. L. Lin, P. Y. Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report here a de novo HLA-DRB1*04 allele, DRB1*04:05:14, discovered in a Taiwanese unrelated volunteer bone marrow stem cell donor by a sequence-based typing method. In exon 2, the DNA sequence of DRB1*04:05:14 is identical to the sequence of DRB1*04:05:01 except the nucleotide at positions 321 where C is replaced by T (at codon 78; TAC→TAT). Due to the silent mutation, the nucleotide substitution produced no amino acid variation in comparison with DRB1*04:05:01. We assume DRB1*04:05:14 was derived from DRB1*04:05:01 via a point mutation. The probable HLA-A, -B and -DRB1 haplotype in association with DRB1*04:05:14 may be deduced as A*11-B*55-DRB1*04:05:14. We here report the Taiwanese ethnicity of DRB1*04:05:14.

Original languageEnglish
Pages (from-to)326-327
Number of pages2
JournalInternational Journal of Immunogenetics
Volume40
Issue number4
DOIs
Publication statusPublished - Aug 1 2013
Externally publishedYes

Fingerprint

Hematopoietic Stem Cells
Nucleotides
Alleles
Tissue Donors
HLA-A Antigens
HLA-B Antigens
Point Mutation
Codon
Bone Marrow Cells
Haplotypes
Volunteers
Exons
Stem Cells
Amino Acids
HLA-DRB1*04 antigen
Silent Mutation

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Immunology
  • Genetics(clinical)
  • Medicine(all)

Cite this

Discovery of the novel HLA-DRB1*04 : 05:14 allele in a Taiwanese unrelated haematopoietic stem cell donor by a sequence-based typing method. / Yang, K. L.; Lee, S. K.; Kao, R. H.; Lin, C. L.; Lin, P. Y.

In: International Journal of Immunogenetics, Vol. 40, No. 4, 01.08.2013, p. 326-327.

Research output: Contribution to journalArticle

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