Discovering imaging endophenotypes for major depression

G. Hasler, G. Northoff

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Psychiatry research lacks an in-depth understanding of mood disorders phenotypes, leading to limited success of genetics studies of major depressive disorder (MDD). The dramatic progress in safe and affordable magnetic resonance-based imaging methods has the potential to identify subtle abnormalities of neural structures, connectivity and function in mood disordered subjects. This review paper presents strategies to improve the phenotypic definition of MDD by proposing imaging endophenotypes derived from magnetic resonance spectroscopy measures, such as cortical gamma-amino butyric acid (GABA) and glutamate/glutamine concentrations, and from measures of resting-state activity and functional connectivity. The proposed endophenotypes are discussed regarding specificity, mood state-independence, heritability, familiarity, clinical relevance and possible associations with candidate genes. By improving phenotypic definitions, the discovery of new imaging endophenotypes will increase the power of candidate gene and genome-wide associations studies. It will also help to develop and evaluate novel therapeutic treatments and enable clinicians to apply individually tailored therapeutic approaches. Finally, improvements of the phenotypic definition of MDD based on neuroimaging measures will contribute to a new classification system of mood disorders based on etiology and pathophysiology.

Original languageEnglish
Pages (from-to)604-619
Number of pages16
JournalMolecular Psychiatry
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Fingerprint

Endophenotypes
Major Depressive Disorder
Depression
Mood Disorders
Butyric Acid
Genome-Wide Association Study
Glutamine
Neuroimaging
Genes
Psychiatry
Glutamic Acid
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Phenotype
Therapeutics
Research

Keywords

  • affective disorders
  • genetics
  • intermediate phenotype
  • MRI
  • MRS
  • neuroimaging

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Discovering imaging endophenotypes for major depression. / Hasler, G.; Northoff, G.

In: Molecular Psychiatry, Vol. 16, No. 6, 06.2011, p. 604-619.

Research output: Contribution to journalArticle

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