Disappearing Calvarium in Gorham Disease

MR Imaging Characteristics with Pathologic Correlation

Chung Ping Lo, Cheng Yu Chen, Shy Chyi Chin, Chun Jung Juan, Chun Jen Hsueh, Ann Chen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Gorham disease is a rare condition characterized by intraosseous neoplastic proliferation of hemangiomatous tissue with progressive, massive osteolysis. We present a pathologically proved case of Gorham disease that involved the left parietal bone in a 23-year-old man. Imaging studies including conventional radiography of the skull, CT, MR imaging, and Technetium-99 m (Tc-99 m) scintigraphy demonstrated a large skull defect without associated soft tissue mass over the left parietal skull. Contrast enhancement and increased isotope uptake along the margin of the defect were shown at gadolinium-enhanced Tl-weighted MR imaging and Tc-99 m methylene diphosphate (Tc-99 m MDP) bone scintigraphy. Pathologic study revealed intraosseous angiomatosis at the periphery of the osteolytic skull lesion.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume25
Issue number3
Publication statusPublished - Mar 2004
Externally publishedYes

Fingerprint

Essential Osteolysis
Skull
Technetium
Radionuclide Imaging
Angiomatosis
Parietal Bone
Diphosphates
Gadolinium
Radiography
Isotopes
Bone and Bones

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Disappearing Calvarium in Gorham Disease : MR Imaging Characteristics with Pathologic Correlation. / Lo, Chung Ping; Chen, Cheng Yu; Chin, Shy Chyi; Juan, Chun Jung; Hsueh, Chun Jen; Chen, Ann.

In: American Journal of Neuroradiology, Vol. 25, No. 3, 03.2004, p. 415-418.

Research output: Contribution to journalArticle

Lo, Chung Ping ; Chen, Cheng Yu ; Chin, Shy Chyi ; Juan, Chun Jung ; Hsueh, Chun Jen ; Chen, Ann. / Disappearing Calvarium in Gorham Disease : MR Imaging Characteristics with Pathologic Correlation. In: American Journal of Neuroradiology. 2004 ; Vol. 25, No. 3. pp. 415-418.
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