Abstract
Polyvinylpyrrolidone (PVP) in aqueous solution was used as a binding agent in a fluidized-bed system to agglomerate acetaminophen powder into directly compressible granules. It was found that a minimal amount of 5% w/w PVP in a concentration of 7.5% w/v or less was needed to produce granules with an acceptable flow and the corresponding tablets having enough hardness without capping. There was a strong correlation between the time for 80% dissolved (T80) and the logarithm of granule volume-surface mean diameter. A directly compressible acetaminophen composition to manufacture tablets having a T80 value less than 30 min can be prepared simply by adding an appropriate amount of disintegrant (crospovidone, sodium starch glycolate, or pregelatinized starch) to the agglomerated granules.
Original language | English |
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Pages (from-to) | 1911-1922 |
Number of pages | 12 |
Journal | Drug Development and Industrial Pharmacy |
Volume | 20 |
Issue number | 11 |
DOIs | |
Publication status | Published - 1994 |
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry