Directly compressible acetaminophen compositions prepared by fluidized-bed granulation

Cheng Hsiung Lid, Shou Chiung Chen, Yung Chi Lee, Theodore D. Sokoloski, Ming Thau Sheu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Polyvinylpyrrolidone (PVP) in aqueous solution was used as a binding agent in a fluidized-bed system to agglomerate acetaminophen powder into directly compressible granules. It was found that a minimal amount of 5% w/w PVP in a concentration of 7.5% w/v or less was needed to produce granules with an acceptable flow and the corresponding tablets having enough hardness without capping. There was a strong correlation between the time for 80% dissolved (T80) and the logarithm of granule volume-surface mean diameter. A directly compressible acetaminophen composition to manufacture tablets having a T80 value less than 30 min can be prepared simply by adding an appropriate amount of disintegrant (crospovidone, sodium starch glycolate, or pregelatinized starch) to the agglomerated granules.

Original languageEnglish
Pages (from-to)1911-1922
Number of pages12
JournalDrug Development and Industrial Pharmacy
Volume20
Issue number11
DOIs
Publication statusPublished - 1994

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Povidone
Granulation
Acetaminophen
Fluidized beds
Tablets
Chemical analysis
Hardness
Starch
Powders

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry
  • Molecular Medicine

Cite this

Directly compressible acetaminophen compositions prepared by fluidized-bed granulation. / Lid, Cheng Hsiung; Chen, Shou Chiung; Lee, Yung Chi; Sokoloski, Theodore D.; Sheu, Ming Thau.

In: Drug Development and Industrial Pharmacy, Vol. 20, No. 11, 1994, p. 1911-1922.

Research output: Contribution to journalArticle

Lid, Cheng Hsiung ; Chen, Shou Chiung ; Lee, Yung Chi ; Sokoloski, Theodore D. ; Sheu, Ming Thau. / Directly compressible acetaminophen compositions prepared by fluidized-bed granulation. In: Drug Development and Industrial Pharmacy. 1994 ; Vol. 20, No. 11. pp. 1911-1922.
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