Abstract
Polyvinylpyrrolidone (PVP) in aqueous solution was used as a binding agent in a fluidized-bed system to agglomerate acetaminophen powder into directly compressible granules. It was found that a minimal amount of 5% w/w PVP in a concentration of 7.5% w/v or less was needed to produce granules with an acceptable flow and the corresponding tablets having enough hardness without capping. There was a strong correlation between the time for 80% dissolved (T80) and the logarithm of granule volume-surface mean diameter. A directly compressible acetaminophen composition to manufacture tablets having a T80 value less than 30 min can be prepared simply by adding an appropriate amount of disintegrant (crospovidone, sodium starch glycolate, or pregelatinized starch) to the agglomerated granules.
| Original language | English |
|---|---|
| Pages (from-to) | 1911-1922 |
| Number of pages | 12 |
| Journal | Drug Development and Industrial Pharmacy |
| Volume | 20 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 1994 |
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ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Organic Chemistry
- Molecular Medicine
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Directly compressible acetaminophen compositions prepared by fluidized-bed granulation. / Lid, Cheng Hsiung; Chen, Shou Chiung; Lee, Yung Chi; Sokoloski, Theodore D.; Sheu, Ming Thau.
In: Drug Development and Industrial Pharmacy, Vol. 20, No. 11, 1994, p. 1911-1922.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Directly compressible acetaminophen compositions prepared by fluidized-bed granulation
AU - Lid, Cheng Hsiung
AU - Chen, Shou Chiung
AU - Lee, Yung Chi
AU - Sokoloski, Theodore D.
AU - Sheu, Ming Thau
PY - 1994
Y1 - 1994
N2 - Polyvinylpyrrolidone (PVP) in aqueous solution was used as a binding agent in a fluidized-bed system to agglomerate acetaminophen powder into directly compressible granules. It was found that a minimal amount of 5% w/w PVP in a concentration of 7.5% w/v or less was needed to produce granules with an acceptable flow and the corresponding tablets having enough hardness without capping. There was a strong correlation between the time for 80% dissolved (T80) and the logarithm of granule volume-surface mean diameter. A directly compressible acetaminophen composition to manufacture tablets having a T80 value less than 30 min can be prepared simply by adding an appropriate amount of disintegrant (crospovidone, sodium starch glycolate, or pregelatinized starch) to the agglomerated granules.
AB - Polyvinylpyrrolidone (PVP) in aqueous solution was used as a binding agent in a fluidized-bed system to agglomerate acetaminophen powder into directly compressible granules. It was found that a minimal amount of 5% w/w PVP in a concentration of 7.5% w/v or less was needed to produce granules with an acceptable flow and the corresponding tablets having enough hardness without capping. There was a strong correlation between the time for 80% dissolved (T80) and the logarithm of granule volume-surface mean diameter. A directly compressible acetaminophen composition to manufacture tablets having a T80 value less than 30 min can be prepared simply by adding an appropriate amount of disintegrant (crospovidone, sodium starch glycolate, or pregelatinized starch) to the agglomerated granules.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028227561&partnerID=8YFLogxK
U2 - 10.3109/03639049409050218
DO - 10.3109/03639049409050218
M3 - Article
AN - SCOPUS:0028227561
VL - 20
SP - 1911
EP - 1922
JO - Drug Development and Industrial Pharmacy
JF - Drug Development and Industrial Pharmacy
SN - 0363-9045
IS - 11
ER -