Direct formation of S-nitroso silica nanoparticles from a single silica source

Hung Chang Chou, Shih Jiuan Chiu, Ying Ling Liu, Teh Min Hu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Nitric oxide (NO) is a ubiquitous molecule in the body. Because of its multiple pathophysiologic roles, the potential for treating various diseases by the exogenous administration of NO has been under intensive investigation. However, the unstable, radical nature of NO poses a major challenge to the effective delivery of NO. Previously, silica nanoparticles synthesized by the traditional method have been developed into NO-carrying systems. In the present study, for the first time NO-carrying silica nanoparticles were prepared from a single silica precursor using a simple nanoprecipitation method. (3-Mercaptopropyl)-trimethoxysilane (MPTMS) was used as the sole silane source, which was subjected to acid-catalyzed S-nitrosation and condensation reactions in a one-pot organic phase. S-Nitroso silica nanoparticles (SNO-SiNPs) were then produced by injecting a smaller quantity of the organic phase into a larger amount of water without surfactants. Various preparation parameters were tested to obtain optimized conditions. Moreover, a phase diagram demonstrating the ouzo effect was constructed. The prepared SNO-SiNPs were spherical particles with a tunable size in the range of 100-400 nm. The nanoparticles in aqueous dispersions exhibited high colloid stability, possibly resulting from highly negatively charged surfaces. The result of solid-state 29Si NMR shows the predominance of T2 and T3 silicon structures, suggesting that nanoparticles were formed from polycondensed silica species. In conclusion, NO-loaded silica nanoparticles have been directly prepared from a single silane precursor using a surfactant-free, low-energy, one-step nanoprecipitation approach. The method precludes the need for the initial formation of bare particles and subsequent functionalization steps.

Original languageEnglish
Pages (from-to)812-822
Number of pages11
JournalLangmuir
Volume30
Issue number3
DOIs
Publication statusPublished - Jan 28 2014

Fingerprint

Nitric oxide
nitric oxide
Silicon Dioxide
Nitric Oxide
Silica
Nanoparticles
silicon dioxide
nanoparticles
Silanes
Surface-Active Agents
silanes
Surface active agents
surfactants
Condensation reactions
Colloids
Silicon
Dispersions
Phase diagrams
colloids
delivery

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Direct formation of S-nitroso silica nanoparticles from a single silica source. / Chou, Hung Chang; Chiu, Shih Jiuan; Liu, Ying Ling; Hu, Teh Min.

In: Langmuir, Vol. 30, No. 3, 28.01.2014, p. 812-822.

Research output: Contribution to journalArticle

Chou, Hung Chang ; Chiu, Shih Jiuan ; Liu, Ying Ling ; Hu, Teh Min. / Direct formation of S-nitroso silica nanoparticles from a single silica source. In: Langmuir. 2014 ; Vol. 30, No. 3. pp. 812-822.
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