Direct compression acetaminophen: Preparation and functional modification by co-drying with microcrystalline cellulose

J. S. Wu, H. O. Ho, M. T. Sheu

Research output: Contribution to journalArticle

Abstract

In this study, acetaminophen was co-dried with microcrystalline cellulose (MCC) to produce a directly compressible formulation. The effects of co-drying were compared to wet granulation and physical mixing. Two MCC slurries with different particle morphologies and functionalities (bulk density, Carr's index, tensile strength, and rate constant of water uptake) were used in the co-drying process to manipulate powder flowability, bulk density, compactibility, friability and the disintegration ability of the direct compression formulations. Co-drying and wet granulation methods remarkably improved the functionality of acetaminophen as compared to physical mixing. Further, co-drying produced samples with greater bulk density than did wet granulation. The functionality of the coprocessed samples was dependent on the selected MCC. In conclusion, the compactibility and powder flowability of acetaminophen can be modified by co-drying with 10% w/w MCC to prepare direct compression formulations. The functionality of the direct compression formulation could be manipulated by selection of MCC.

Original languageEnglish
Pages (from-to)151-165
Number of pages15
JournalChinese Pharmaceutical Journal
Volume52
Issue number3
Publication statusPublished - 2000

Fingerprint

Acetaminophen
Cellulose
Drying
Granulation
Powders
Tensile Strength
Disintegration
Slurries
Rate constants
Tensile strength
microcrystalline cellulose
Water

Keywords

  • Acetaminophen
  • Co-drying
  • Microcrystalline cellulose

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science

Cite this

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title = "Direct compression acetaminophen: Preparation and functional modification by co-drying with microcrystalline cellulose",
abstract = "In this study, acetaminophen was co-dried with microcrystalline cellulose (MCC) to produce a directly compressible formulation. The effects of co-drying were compared to wet granulation and physical mixing. Two MCC slurries with different particle morphologies and functionalities (bulk density, Carr's index, tensile strength, and rate constant of water uptake) were used in the co-drying process to manipulate powder flowability, bulk density, compactibility, friability and the disintegration ability of the direct compression formulations. Co-drying and wet granulation methods remarkably improved the functionality of acetaminophen as compared to physical mixing. Further, co-drying produced samples with greater bulk density than did wet granulation. The functionality of the coprocessed samples was dependent on the selected MCC. In conclusion, the compactibility and powder flowability of acetaminophen can be modified by co-drying with 10{\%} w/w MCC to prepare direct compression formulations. The functionality of the direct compression formulation could be manipulated by selection of MCC.",
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T2 - Preparation and functional modification by co-drying with microcrystalline cellulose

AU - Wu, J. S.

AU - Ho, H. O.

AU - Sheu, M. T.

PY - 2000

Y1 - 2000

N2 - In this study, acetaminophen was co-dried with microcrystalline cellulose (MCC) to produce a directly compressible formulation. The effects of co-drying were compared to wet granulation and physical mixing. Two MCC slurries with different particle morphologies and functionalities (bulk density, Carr's index, tensile strength, and rate constant of water uptake) were used in the co-drying process to manipulate powder flowability, bulk density, compactibility, friability and the disintegration ability of the direct compression formulations. Co-drying and wet granulation methods remarkably improved the functionality of acetaminophen as compared to physical mixing. Further, co-drying produced samples with greater bulk density than did wet granulation. The functionality of the coprocessed samples was dependent on the selected MCC. In conclusion, the compactibility and powder flowability of acetaminophen can be modified by co-drying with 10% w/w MCC to prepare direct compression formulations. The functionality of the direct compression formulation could be manipulated by selection of MCC.

AB - In this study, acetaminophen was co-dried with microcrystalline cellulose (MCC) to produce a directly compressible formulation. The effects of co-drying were compared to wet granulation and physical mixing. Two MCC slurries with different particle morphologies and functionalities (bulk density, Carr's index, tensile strength, and rate constant of water uptake) were used in the co-drying process to manipulate powder flowability, bulk density, compactibility, friability and the disintegration ability of the direct compression formulations. Co-drying and wet granulation methods remarkably improved the functionality of acetaminophen as compared to physical mixing. Further, co-drying produced samples with greater bulk density than did wet granulation. The functionality of the coprocessed samples was dependent on the selected MCC. In conclusion, the compactibility and powder flowability of acetaminophen can be modified by co-drying with 10% w/w MCC to prepare direct compression formulations. The functionality of the direct compression formulation could be manipulated by selection of MCC.

KW - Acetaminophen

KW - Co-drying

KW - Microcrystalline cellulose

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