Direct and selective metal-free N6-arylation of adenosine residues for simple fluorescence labeling of DNA and RNA

Guralamatta Siddappa Ravi Kumara, Anup Pandith, Young Jun Seo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We have developed an unprecedented transition metal-free approach for the direct fluorescence turn-on labeling of natural oligonucleotides through selective N6-arylation of adenosine moieties. This method allows the simple and direct fluorescence labeling of natural unmodified DNA and RNA, but is dependent on the secondary structure, favoring single-stranded structures.

Original languageEnglish
Pages (from-to)5450-5453
Number of pages4
JournalChemical Communications
Volume57
Issue number44
DOIs
Publication statusPublished - Jun 4 2021
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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