Diosgenin, a plant-derived sapogenin, enhances regulatory T-Cell immunity in the intestine of mice with food allergy

Chung Hsiung Huang, Der Zen Liu, Tong Rong Jan

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

It was hypothesized that the suppressive effect of diosgenin (1) on the intestinal T helper (Th)2 responses is associated with an enhancement of the regulatory T-cell immunity. Ovalbumin (OVA)-sensitized BALB/c mice were gavaged daily with 1 and received repeatedly oral OVA challenges to induce intestinal allergic responses. The expression of Th2-and Treg-related cytokines and transcription factors was examined by immunohistochemical staining and RT-PCR. Administration of 1 markedly attenuated the intestinal expression of interleukin (IL)-4 and GATA3. In addition, administration of 1 reversed the diminished density of intestinal Foxp3+ cells induced by OVA oral challenges and enhanced the expression of IL-10 by Foxp3+ cells markedly. These results suggest that the suppressive effect of 1 on allergen-induced intestinal Th2 responses is closely associated with an up-regulation of the regulatory T-cell immunity in the inflammatory site.

Original languageEnglish
Pages (from-to)1033-1037
Number of pages5
JournalJournal of Natural Products
Volume73
Issue number6
DOIs
Publication statusPublished - Jun 25 2010

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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